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Promotion of mefenamic acid nucleation by a surfactant additive, docusate sodium

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dc.contributor.author Bodnár, Katalin
dc.contributor.author Hudson, Sarah P.
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2019-02-08T09:49:59Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7564
dc.description peer-reviewed en_US
dc.description.abstract The influence of docusate sodium (DOSS) on the nucleation of mefenamic acid (MEF) has been studied in different dimethylacetamide (DMA)–water mixtures. A series of induction time experiments were conducted under moderate supersaturations, varying the solvent composition and the concentration of DOSS. In 40% DMA–60% water, the presence of 0.1 and 0.2 mg/mL DOSS increased the nucleation rate. Evaluating the results by the classical nucleation theory reveals that the pre-exponential factor (A) increases by approximately 50% while the interfacial energy is essentially uninfluenced. It is also found that the crystal growth rate becomes higher in the presence of DOSS. It is thus hypothesized that transport and desolvation of MEF molecules are facilitated in the presence of DOSS. With increasing amount of DMA in the binary solvent mixture, the influence of DOSS appears to decrease. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 12RC2275 en_US
dc.relation.ispartofseries Crystal Growth and Design;19 (2), pp. 591-603
dc.relation.uri https://doi.org/10.1016/j.compstruct.2019.01.069
dc.rights © Year ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work seehttp://dx.doi.org/10.1021/acs.cgd.8b00995 en_US
dc.subject crystal growth en_US
dc.title Promotion of mefenamic acid nucleation by a surfactant additive, docusate sodium en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.compstruct.2019.01.069
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Irish Government’s Programme for Research in Third Level Institutions Cycle 5
dc.relation.projectid 12/RC/2275 en_US
dc.date.embargoEndDate 2019-12-18
dc.embargo.terms 2019-12-18 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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