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The nature of urgency

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dc.contributor.advisor Coffey, Calvin J.
dc.contributor.advisor Flood, Hugh D.
dc.contributor.author Redmond, Elaine Joanne
dc.date.accessioned 2019-02-06T11:13:11Z
dc.date.available 2019-02-06T11:13:11Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7553
dc.description peer-reviewed en_US
dc.description.abstract Introduction: Many self-help guides advise patients that spreading fluid intake throughout the day can reduce symptoms of overactive bladder (OAB).A,B However, although animal studies suggest a link between faster filling rates and increased afferent nerve firing, the relationship between filling rate and bladder sensation has not been examined in humans. The aim of this research is to investigate the effect of bladder volume and rate of bladder filling on bladder sensation and voiding patterns, in the physiological and pathological bladder in a non-clinical, natural filling environment. Methods: Forty female volunteers (control group) were recruited by open advertisement. A further 24 female patients with OAB were recruited from the urology outpatients department. Each participant completed a UDI-6, IIQ-7 and 3-day sensation-related bladder diary. Results: There was a negative correlation between the rate of bladder filling and the length of intervoiding interval in both groups (p=<0.001). There was a positive correlation between the voided volume and the length of intervoiding interval in both groups (p=<0.001). The proportion of urgent voids in the control group increased with increasing voided volumes (p=<0.001) and bladder filling rates (p=<0.001). The proportion of urgent voids in patients with OAB also increased with increasing voided volumes (p=0.004) and bladder filling rates (p=0.013). On regression analysis the rate of bladder filling was an independent predictor of urgent voids in patients with OAB but not in the control group. Women with OAB were less tolerant of higher bladder filling rates and experienced most grades of bladder sensation at significantly lower voided volumes and filling rates than the control group. Conclusion: The rate of bladder filling appears to influence the length of intervoiding interval and sensation associated with each void. Advising patients on strategies to lower their bladder filling rate should help reduce urinary frequency, urgency and urge incontinence. en_US
dc.language.iso eng en_US
dc.publisher University of Limerick en_US
dc.subject patients en_US
dc.subject overactive bladder en_US
dc.subject urgency en_US
dc.subject urge incontinence en_US
dc.title The nature of urgency en_US
dc.type info:eu-repo/semantics/doctoralThesis en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.supercollection ul_theses_dissertations en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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