• P071 The mesentery in Crohn's disease displays mesenchymal abnormalities. 

  Walsh, Leon; Kiernan, Miranda G; Sahebally, Shaheel; Kiely, Patrick A; Waldron, David; Moloney, M; Skelly, M; Hidayat, H; Faul, P; O'Leary, D.P; O'Leary, Peter D; Lowery, Aoife; Dunne, Colum; Coffey, Calvin J (Oxford University Press, 2017)

  Background: Recent advances in our understanding of mesenteric anatomy have shown that the mesentery is continuous along the intestinal tract at vascular, lymphatic and connective tissue levels [1]. Thus, the mesentery ...
• P026 The role of fibrocytes in mesenteric Crohn's disease. 

  Kiernan, Miranda G; Sahebally, S.M; Kiely, Patrick A; Waldron, David; Moloney, M; Skelly, M; Faul, P.N; O'Leary, D.P; Lowery, Aoife J; Walsh, L.G; Dunne, Colum; Coffey, John C (Oxford University Press, 2017)

  The mesentery in Crohn’s disease frequently displays disease manifestations, such as mesenteric thickening and fat wrapping. Fibrocytes are a precursor cell type that can differentiate into fibroblasts or adipocytes [1]. ...
• P216 Mesenteric disease is directly related to mucosal disease in Crohn's disease. 

  Kiernan, Miranda G; Sahebally, S.M; Waldron, David; Moloney, M; Skelly, M; HIdayat, H; O'Leary, D.P; Lowery, Aoife J; Walsh, L.G; Dunne, Colum; Coffey, John C (Oxford University Press, 2017)

  Crohn’s disease (CD) displays mesenteric disease manifestations such as fat wrapping and mesenteric thickening. The frequency at which these occur in CD point to a pathobiological relevance. Fat wrapping in particular ...
• Anti-microbial coating innovations to prevent healthcare-associated infection 

  Crijns, F.R.L; Keinänen-Toivola, M.M; Dunne, Colum (Elsevier, 2017)

  Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European hospitals on any given day.1 This represents not only a public health risk, ...
• Subsyndromal delirium compared to delirium, dementia, and subjects without delirium or dementia in elderly general hospital admissions and nursing home residents 

  Sepulveda, Esteban; Leonard, Maeve; Franco, Jose G; Adamis, Dimitrios; McCarthy, Geraldine; Dunne, Colum; Trzepacz, Paula T; Gaviria, Ana M; de Pablo, Joan; Vilella, Elisabet; Meagher, David (Elsevier, 2017)

  Introduction: Subsyndromal delirium (SSD) complicates diagnosis of delirium and dementia, although there is little research comparing their symptom profiles. Methods: Cross-sectional study of 400 elderly patients’ admission ...
• Sleep-wake cycle disturbances in elderly acute general medical inpatients: longitudinal relationship to delirium and dementia. 

  Fitzgerald, James M; O'Regan, Niamh; Adamis, Dimitrios; Timmons, Suzanne; Dunne, Colum; Trzepacz, Paula T; Meagher, David (Elsevier, 2017)

  Introduction: Sleep disturbances in elderly medical inpatients are common, but their relationship to delirium and dementia has not been studied. Methods: Sleep and delirium status were assessed daily for a week in 145 ...
• Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification 

  Hayes, Christopher J; Dowling, Catríona M; Dwane, Susan; McCumiskey, Mary E; Tormey, Shona M; Merrigan, Anne; Coffey, John C; Kiely, Patrick A; Dalton, Tara M (AIP Publishing, 2016)

  In cancer, biomarkers have many potential applications including generation of a differential diagnosis, prediction of response to treatment, and monitoring disease progression. Many molecular biomarkers have been put ...
• Exercise portrayal in children's television programmes: analysis of United Kingdom and Irish programming. 

  Scully, Paul; Reid, Orlaith; Macken, Alan P; Healy, Mark; Saunders, Jean; Leddin, Des; Dunne, Colum; O'Gorman, Clodagh S (Dove Medical Press, 2016)

  Background: Television watching is obesogenic due to its sedentary nature and programming content, which influences children. Few studies have examined exercise placement within children-specific programming. This study ...
• The first occurence of a CTX-M ESBL-producing Escherichia coli outbreak mediated by mother to neonate transmission in an Irish neonatal intensive care unit. 

  O'Connor, Ciara; Philip, Roy K; Kelleher, John; Powell, James; O'Gorman, Alan; Slevin, Barbara; Woodford, Neil; Turton, Jane F; McGrath, Elaine; Finnegan, Cathriona; Power, Lorraine; O'Connell, Nuala H; Dunne, Colum (BioMed Central, 2017)

  Background: Escherichia coli (E. coli) comprise part of the normal vaginal microflora. Transfer from mother to neonate can occur during delivery resulting, sometimes, in neonatal bacterial disease. Here, we aim to report ...
• An optimised work-flow to reduce time-to-detection of carbapenemase-producing Enterobacteriaceae (CPE) using direct testing from rectal swabs 

  O'Connor, Ciara; Kiernan, Miranda G; Finnegan, Cathriona; O'Hara, M; Power, Lorraine; O'Connell, Nuala H; Dunne, Colum (Taylor and Francis, 2016)

  Rapid detection of patients with carbapenem-producing Enterobacteriaceae (CPE) is essential for the prevention of nosocomial cross-transmission, allocation of isolation facilities and to protect patient safety. Here, we ...
• An Irish outbreak of New Delhi metallo-β-lactamase (NDM)-1 carbapenemase-producing Enterobacteriaceae: increasing but unrecognised prevalence 

  O'Connor, Ciara; Cormican, Martin; Wee Boo, Teck; McGrath, Elaine; Slevin, Barbara; O'Gorman, Alan; Commane, Marion; Mahony, Stephane; O'Donovan, Eimear; Powell, James; Monahan, Regina; Finnegan, Cathriona; Kiernan, Miranda G; Coffey, Calvin J; Power, Lorraine; O'Connell, Nuala H; Dunne, Colum (Elsevier, 2016)

  Background Carbapenemase-producing Enterobacteriaceae (CPE) can cause healthcare–associated infections with high mortality rates. New Delhi metallo-beta-lactamase-1 (NDM-1) is amongst the most recently discovered ...
• Colonisation with extended-spectrum beta-lactamase (ESBL) not detected in a prevalence study. 

  O'Connor, Ciara; Kiernan, Miranda G; Finnegan, Cathriona; Powell, James; Power, Lorraine; O'Connell, Nuala H; Dunne, Colum (Springer, 2016)

  Background The Mid-West of Ireland has higher than average national rates of invasive extended-spectrum beta-lactamase (ESBL) bloodstream infections and carbapenemase-producing Enterobacteriaceae (CPE), with increasing ...
• Food and beverage cues in children's television programmes: the influence of programme genre 

  Scully, Paul; Reid, Orlaith; Macken, Alan P; Healy, Mark; Saunders, Jean; Leddin, Des; Cullen, Walter; Dunne, Colum; O'Gorman, Clodagh S (Cambridge University Press, 2016)

  Objective: The link between childhood obesity and both television viewing and television advertising have previously been examined. We sought to investigate the frequency and type of food and beverage placements in ...
• Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time 

  Murphy, Sylvia M; Kiely, Maeve; Jakeman, Philip M; Kiely, Patrick A; Carson, Brian P (Portland Press, 2016)

  The importance of growth and maintenance of skeletal muscle is vital for long term health and quality of life. Appropriate nutrition with specific bioactivities relevant to the functionalities of tissues such as skeletal ...
• Combined education and skin antisepsis intervention for persistently high blood-culture contamination rates in neonatal intensive care 

  O'Connor, Ciara; Philip, Roy K; Powell, James; Slevin, Barbara; Quinn, Catherine; Power, Lorraine; O'Connell, Nuala H; Dunne, Colum (Elsevier, 2016)

  Contaminated blood cultures represent challenges regarding diagnosis, duration of hospitalization, antimicrobial use, pharmacy and laboratory costs. Facing problematic neonatal blood culture contamination (3.8%), we ...
• Fibrocytes contribute to mesenteric manifestations in Crohn s disease 

  Kiernan, Miranda G; Sahebally, S.M; Jarrar, A; Burke, J.P; Hogan, J; Kiely, Patrick A; Shen, B; Moloney, M; Skelly, M; Leddin, D; Hedayat, H; Faul, P.N; Healy, V; O'Connell, Ronan P; Martin, S; Shanahan, Fergus; Dunne, Colum; Coffey, John C (Springer, 2016)

  no abstract available
• Regulation and registration as drivers of continuous professional competence for Irish pre-hospital practitioners: a discussion paper. 

  Knox, Shane; Dunne, Suzanne S.; Hughes, M; Cheeseman, S; Dunne, Colum (Springer, 2016)

  Background The Regulatory Body responsible for the registration of Irish pre-hospital practitioners, the Pre-Hospital Emergency Care Council (PHECC), identified the need to implement a continuing professional competence ...
• Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival 

  Dowling, Catríona M; Phelan, James; Callender, Julia A; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, John C; Newton, Alexandra C; O'Sullivan, Jacintha; Kiely, Patrick A (Impact Journals, 2016)

  Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
• Beliefs, perceptions and behaviours of GPs towards generic medicines. 

  Dunne, Suzanne S.; Shannon, Bill; Cullen, Walter; Dunne, Colum (HSE, 2016)

  no abstract available
• The association between maternal perceptions of own weight status and weight status of her child: results from a national cohort study 

  Dowd, Kieran P; Kirwan, Robert P; Hannigan, Ailish; Purtill, Helen; O'Gorman, Clodagh S (BMJ Publishing Group, 2015)

  Objectives: To examine the relationship between maternal self-reported and measured height and weight, maternal perceived weight status and measured body mass index (BMI), and maternal perceived child weight status and ...

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