• Hand-hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review 

  Clancy, C.; Delungahawatta, T.; Dunne, Colum P. (Elsevier, 2021)

  Background: There is general consensus that hand hygiene is the most effective way to prevent healthcare-associated infections. However, low rates of compliance amongst healthcare workers have been reported globally. The ...
• The lung microbiome in young children with cystic fibrosis: A prospective cohort study 

  Linnane, Barry; Walsh, Aaron M.; Walsh, Calum J.; Crispie, Fiona; O'Sullivan, Orla; Cotter, Paul D.; McDermott, Michael; Renwick, Julie; McNally, Paul (MDPI, 2021)

  The cystic fibrosis (CF) lung harbours a diverse microbiome and reduced diversity in the CF lung has been associated with advancing age, increased inflammation and poorer lung function. Data suggest that the window for ...
• Liver function tests in F508del homozygous paediatric patients with cystic fibrosis taking lumacaftor/ivacaftor combination therapy 

  Paluck, F.; Power, N.; Lynch, C.; Cox, D.; McNally, P.; Rowland, M; Bourke, B; Linnane, Barry (Springer, 2021)

  In clinical trials, elevated liver transaminase levels in patients taking lumacaftor/ivacaftor therapy were reported. Our aim was to assess in clinical practice, whether F508del homozygous paediatric CF patients had a ...
• Outcomes of point-of-care testing for influenza in the emergency department of a tertiary referral hospital in Ireland 

  Teoh, T.K.; Powell, J; Kelly, J.; McDonnell, C.; Whelan, R; O'Connell, N.H.; Dunne, Colum P. (Elsevier, 2021)

  Background: Seasonal influenza causes significant morbidity and mortality, and represents a recurring financial burden for community- and hospital-based treatment. Nosocomial outbreaks exacerbate the impact of influenza. ...
• Designing new antibacterial wound dressings: development of a dual layer cotton material coated with poly(vinyl alcohol)_chitosan nanofibers incorporating agrimonia eupatoria L. extract 

  Mouro, Cláudia; Dunne, Colum P.; Gouvei, Isabel C. (MDPI, 2021)

  Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced ...
• Role of circulating fibrocytes in the diagnosis of acute appendicitis 

  Zarog, M. A.; O'Leary, D. P.; Kiernan, M. G.; Bolger, J.; Tibbitts, P.; Coffey, S. N.; Lowery, A.; Byrnes, G. J.; Peirce, C.; Dunne, Colum P.; Coffey, J. C. (Wiley, 2020)

  Background: Improved diagnostic biomarkers are required for acute appendicitis. The circulating fibrocyte percentage (CFP) is increased in inflammatory states, but has not been studied in acute appendicitis. This study ...
• Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing analysis of data from the prior two decades 

  Philip, Roy K.; Purtill, Helen; Reidy, Elizabeth; Daly, Mandy; Imcha, Mendinaro; McGrath, Deirdre; O'Connell, Nuala H; Dunne, Colum P. (BMJ, 2020)

  Aetiology of births involving very low birthweight (VLBW) and extremely low birthweight (ELBW) infants is heterogeneous and preventive strategies remain elusive. Socioenvironmental measures implemented as Ireland’s ...
• Proposed hypothesis and rationale for association between mastitis and breast cancer 

  Nolan, Joanne; Dunne, Suzanne S.; Mustafa, Wed; Sivananthan, Laxsanaa; Kiely, Patrick A.; Dunne, Colum P. (Elsevier, 2020)

  Breast cancer is amongst the most common forms of cancer, is predominantly a woman’s illness, and is the most frequently reported invasive cancer in women worldwide (Bray et al., 2018). Varying risk factors have been ...
• The effect of whey protein supplementation on myofibrillar protein synthesis and performance recovery in resistance-trained men 

  Davies, Robert W.; Bass, Joseph J.; Carson, Brian P.; Norton, Catherine; Kozior, Marta; Wilkinson, Daniel J.; Brook, Matthew S.; Atherton, Philip J.; Smith, Ken; Jakeman, Philip M. (MDPI, 2020)

  Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). ...
• Management of staphylococcus aureus bacteraemia (SAB) in the oncology patient: further evidence supports prompt removal of central venous catheters and shorter duration of intravenous antimicrobial therapy 

  Dunne, Colum P.; Ryan, Phelim; Connolly, Roisin; Dunne, Suzanne S.; Kaballo, Mohammed A.; Powell, James; Woulfe, Bernie; O'Connell, Nuala H.; Gupta, Rajnish Kumar (Elsevier, 2020)

  Background Staphylococcus aureus bacteraemia (SAB) is associated with relatively high risk of complications and high levels of mortality. Internationally, SAB management guidelines lack consensus and especially so regarding ...
• Development of a novel technique to dissect the mesentery that preserves mesenteric continuity and enables characterization of the ex vivo mesentery 

  Kumar, Ashutosh; Faiq, Muneeb A.; Krishna, Hare; Kishan, Vijay; Raj, Gladwin V.; Coffey, Calvin J.; Jacob, Tony George (Frontiers Media, 2020)

  Introduction: The conventional model of abdominal anatomy described multiple mesenteries. Dissection techniques were based on this. Recent studies demonstrate the mesentery is continuous from duodenojejunal flexure to ...
• Assessment of the FilmArray® multiplex PCR system and associated meningitis/encephalitis panel in the diagnostic service of a tertiary hospital 

  Mostyn, Amanda; Lenihan, Marie; O'Sullivan, Donnchadh; Woods, Sara; O'Hara, Maureen; Powell, James; Power, Lorraine; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2020)

  Rapid and accurate diagnosis of meningitis/encephalitis (M/E) is essential for successful patient outcomes. The FilmArray® meningitis/encephalitis Panel (MEP) is a multiplexed PCR test for simultaneous, rapid detection of ...
• A cell-based evaluation of a non-essential amino acid formulation as a non-bioactive control for activation and stimulation of muscle protein synthesis using ex vivo human serum 

  Patel, Bijal; Pauk, Martina; Amigo-Benavent, Miryam; Nongonierma, Alice B.; Fitzgerald, Richard J.; Jakeman, Philip M.; Carson, Brian P. (Public Library of Science, 2019)

  The purpose of this study was to compare the effect of treating skeletal muscle cells with media conditioned by postprandial ex vivo human serum fed with either isonitrogenous Non-Essential Amino Acid (NEAA) or a whey ...
• Systemic molecular mediators of inflammation differentiate Between crohn’s disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of pro-inflammatory cytokines in therapy 

  Kiernan, Miranda G.; Coffey, Calvin J.; Sahebally, Shaheel M.; Tibbitts, Paul; Lyons, Emma May; O’Leary, Eimear; Owolabi, Funke; Dunne, Colum P. (Oxford University Press, 2019)

  Background and Aims: Faecal diversion is associated with improvements in Crohn’s disease but not ulcerative colitis, indicating that differing mechanisms mediate the diseases. This study aimed to investigate levels of ...
• Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata 

  Ryan, Phelim; Motherway, Catherine; Powell, James; Elsaka, Ahmed; Ali Sheikh, Ambreen; Jahangir, Azhar; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2019)

  The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata ...
• Regulation of GLUT4 translocation in an in vitro cell model using postprandial human serum ex vivo 

  Cogan, Karl E.; Carson, Brian P.; Patel, Bijal; Amigo-Benavent, Miryam; Jakeman, Philip M.; Egan, Brendan (Wiley and Sons Ltd, 2019)

  Individual amino acids, amino acid mixtures and protein hydrolysates stimulate glucose uptake in many experimental models. To replicate better in vitro the dynamic postprandial response to feeding in vivo, in the present ...
• Differential stimulation of post-exercise myofibrillar protein synthesis in humans following isonitrogenous, isocaloric pre-exercise feeding 

  Davies, Robert W.; Bass, Joseph J.; Carson, Brian P.; Norton, Catherine; Kozior, Marta; Amigo-Benavent, Miryam; Wilkinson, Daniel J.; Brook, Matthew S.; Atherton, Philip J.; Smith, Kenneth; Jakeman, Philip M. (MDPI, 2019)

  .The aim of this study was to test the effects of two disparate isonitrogenous, isocaloric pre-exercise feeds on deuterium-oxide (D2O) derived measures of myofibrillar protein synthesis (myoPS) in humans. Methods: In a ...
• Age-group differences in the performance of selected tests of physical function and association with lower extremity strength 

  Francis, Peter; McCormack, William; Lyons, Mark; Jakeman, Philip M. (Lippincott, Williams & Wilkins, 2019)

  . Background and Purpose: It is not known whether short functional performance tests used in aging research are appropriate for use in healthy older adults. The purpose of this study was to investigate age-group ...
• Over prescribing of antibiotics for acute respiratory tract infections; a qualitative study to explore Irish general practitioners’perspectives 

  O'Doherty, Jane; Leader, Leonard F.W.; O'Regan, Andrew; Dunne, Colum P.; Puthoopparambil, Soorej Jose; O'Connor, Ray (BMC, 2019)

  Background: Anti-microbial resistance (AMR) is a global threat to public health and antibiotics are often unnecessarily prescribed for acute respiratory tract infections (ARTIs) in general practice. We aimed to investigate why ...
• Opportunities lost may be the greatest cost of CPE outbreaks 

  Dunne, Colum P.; Slevin, Barbara L.; O'Connell, Nuala H. (Elsevier, 2019)

  no abstract available

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