• Outcomes of implementation of the FilmArray meningoencephalitis panel in a tertiary hospital between 2017 and 2020 

  Teoh, TeeKeat; Powell, James; O'Keeffe, Jillian; Donlon, Eoghan; Dillon, Lisa; Lenihan, Marie; Mostyn, Amanda; Power, Lorraine; Boers, Peter; Stapleton, Patrick J.; O'Connell, Nuala H.; Dunne, Colum P. (Public Library of Science, 2022)

  Acute meningoencephalitis is encountered commonly in the acute hospital setting and is associated with significant morbidity and mortality, in addition to significant healthcare costs. Multiplex PCR panels now allow ...
• Irish SARS-CoV-2 convalescent serological status of children following acute pneumonia during Ireland’s first wave 

  Irfan, S. Sabir; Flinn, K.; Mullane, D.; Murray, D.M.; Linnane, Barry; Holder, P.; De Gascun, C.; NíChróinín, M. (IMO, 2022)

  A global epidemic caused by a novel coronavirus (SARS-CoV-2) in China in December 2019 has spread worldwide¹. We hypothesised that due to low levels of viral shedding in children's upper airways, many children with ...
• An initial evaluation of the safety of a disposable oscillating positive expiratory pressure device in patients with chronic obstructive pulmonary disease: a short-term pilot study 

  O'Sullivan, Kevin Jeremiah; Power, Valerie; Linnane, Barry; McGrath, Deirdre; Fogarty, Hilda; Ryan, Martina; White, Rebecca; Noonan, Conor; Mulloy, Eithne; O'Sullivan, Leonard; Dunne, Colum P. (BMC, 2021)

  Background: Handheld oscillating positive expiratory pressure (OPEP) devices have been a mainstay of treatment for patients with hypersecretory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary ...
• A retrospective observational study of the impact of 16s and 18s ribosomal RNA PCR on antimicrobial treatment over seven years: A tertiary hospital experience 

  Teoh, TeeKeat; McNamara, Rachel; Powell, James; O'Connell, Nuala H.; Dunne, Colum P. (Public Library of Science, 2021)

  Although culture-based methods remain a staple element of microbiology analysis advanced molecular methods increasingly supplement the testing repertoire. Since the advent of 16s and 18s ribosomal RNA PCR in the 2000s, ...
• Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission 

  Dowling, Lisa; Jakeman, Philip M.; Norton, Catherine; Skelly, Maeve; Yousuf, Hamid; Kiernan, Miranda G.; Toomey, Margaret; Bowers, Sheila; Dunne, Suzanne S.; Coffey, Calvin J.; Dunne, Colum P. (SpringerNature, 2021)

  Crohn’s disease (CD) is a debilitating inflammatory bowel condition of unknown aetiology that is growing in prevalence globally. Large-scale studies have determined associations between female obesity or low body mass ...
• Prevalence of linezolid‑resistant organisms among patients admitted to a tertiary hospital for critical care or dialysis 

  Dembicka, Kornelia Maria; Powell, James; O'Connell, Nuala H.; Hennessy, Noreen; Brennan, Grainne; Dunne, Colum P. (Springer, 2021)

  Background Linezolid is an oxazolidinone antimicrobial regarded as a “last resort” antimicrobial, used typically for treatment of Gram-positive bacterial infections. It is acknowledged that prevalence of resistance to ...
• Flexural properties and failure mechanisms of infusible thermoplastic-and thermosetting based composite materials for marine applications 

  Gobikannan, T.; Portela, Alexandre; Haldar, A.K.; Nash, N.H.; Bachour, C.; Manolakis, Ioannis; Comer, A.J. (Elsevier, 2021)

  This study aims to evaluate the flexural properties and associated failure mechanisms of a reactive thermoplastic relative to traditional thermosetting resin systems (polyester, vinylester, epoxy) for potential application ...
• The development and structure of the mesentery 

  Byrnes, Kevin G.; Walsh, Dara; Walsh, Leon G.; Coffey, Domhnall M.; Ullah, Muhammad Fahad; Mirapeix, Rosa; Hikspoors, Jill; Lamers, Wouter; Wu, Yi; Zhang, Xiao-Qin; Zhang, Shao-Xiang; Brama, Pieter; Dunne, Colum P.; O'Brien, Ian S.; Peirce, Colin; Shelly, Martin J.; Scanlon, Tim G.; Luther, Mary E.; Brady, Hugh D.; Dockery, Peter; McDermott, Kieran W.; Coffey, Calvin J. (Nature, 2021)

  The position of abdominal organs, and mechanisms by which these are centrally connected, are currently described in peritoneal terms. As part of the peritoneal model of abdominal anatomy, there are multiple mesenteries. ...
• Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 

  Linnane, Barry; O'Connell, Nuala H.; Obande, E.; Dunne, Suzanne S.; Clancy, C.; Kiernan, Miranda G.; McGrath, D.; O'Sullivan, Kevin Jeremiah; O'Sullivan, Leonard; Dunne, Colum P. (Elsevier, 2021)

  Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination ...
• Biomarkers in delirium: A systematic review 

  Dunne, Suzanne S.; Coffey, Calvin J.; Konje, Swiri; Gasior, Sara; Clancy, Conor C.; Gulati, Gautam; Meagher, David; Dunne, Colum P. (Elsevier, 2021)

  Background: Delirium is a common neuropsychiatric disorder associated with prolonged hospital stays, and increased morbidity and mortality. Diagnosis is frequently missed due to varying disease presentation and lack of ...
• Hand-hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review 

  Clancy, C.; Delungahawatta, T.; Dunne, Colum P. (Elsevier, 2021)

  Background: There is general consensus that hand hygiene is the most effective way to prevent healthcare-associated infections. However, low rates of compliance amongst healthcare workers have been reported globally. The ...
• The lung microbiome in young children with cystic fibrosis: A prospective cohort study 

  Linnane, Barry; Walsh, Aaron M.; Walsh, Calum J.; Crispie, Fiona; O'Sullivan, Orla; Cotter, Paul D.; McDermott, Michael; Renwick, Julie; McNally, Paul (MDPI, 2021)

  The cystic fibrosis (CF) lung harbours a diverse microbiome and reduced diversity in the CF lung has been associated with advancing age, increased inflammation and poorer lung function. Data suggest that the window for ...
• Liver function tests in F508del homozygous paediatric patients with cystic fibrosis taking lumacaftor/ivacaftor combination therapy 

  Paluck, F.; Power, N.; Lynch, C.; Cox, D.W.; McNally, Paul; Rowland, M; Bourke, B; Linnane, Barry (Springer, 2021)

  In clinical trials, elevated liver transaminase levels in patients taking lumacaftor/ivacaftor therapy were reported. Our aim was to assess in clinical practice, whether F508del homozygous paediatric CF patients had a ...
• Outcomes of point-of-care testing for influenza in the emergency department of a tertiary referral hospital in Ireland 

  Teoh, TeeKeat; Powell, J.; Kelly, J.; McDonnell, C.; Whelan, R.; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2021)

  Background: Seasonal influenza causes significant morbidity and mortality, and represents a recurring financial burden for community- and hospital-based treatment. Nosocomial outbreaks exacerbate the impact of influenza. ...
• Designing new antibacterial wound dressings: development of a dual layer cotton material coated with poly(vinyl alcohol)_chitosan nanofibers incorporating agrimonia eupatoria L. extract 

  Mouro, Cláudia; Dunne, Colum P.; Gouveia, Isabel C. (MDPI, 2021)

  Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced ...
• Role of circulating fibrocytes in the diagnosis of acute appendicitis 

  Zarog, M. A.; O'Leary, D.P.; Kiernan, Miranda G.; Bolger, J.; Tibbitts, Paul; Coffey, S. N.; Lowery, A.; Byrnes, G. J.; Peirce, Colin; Dunne, Colum P.; Coffey, Calvin J. (Wiley, 2020)

  Background: Improved diagnostic biomarkers are required for acute appendicitis. The circulating fibrocyte percentage (CFP) is increased in inflammatory states, but has not been studied in acute appendicitis. This study ...
• Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing analysis of data from the prior two decades 

  Philip, Roy K.; Purtill, Helen; Reidy, Elizabeth; Daly, Mandy; Imcha, Mendinaro; McGrath, Deirdre; O'Connell, Nuala H.; Dunne, Colum P. (BMJ, 2020)

  Aetiology of births involving very low birthweight (VLBW) and extremely low birthweight (ELBW) infants is heterogeneous and preventive strategies remain elusive. Socioenvironmental measures implemented as Ireland’s ...
• Proposed hypothesis and rationale for association between mastitis and breast cancer 

  Nolan, Joanne; Dunne, Suzanne S.; Mustafa, Wed; Sivananthan, Laxsanaa; Kiely, Patrick A.; Dunne, Colum P. (Elsevier, 2020)

  Breast cancer is amongst the most common forms of cancer, is predominantly a woman’s illness, and is the most frequently reported invasive cancer in women worldwide (Bray et al., 2018). Varying risk factors have been ...
• The effect of whey protein supplementation on myofibrillar protein synthesis and performance recovery in resistance-trained men 

  Davies, Robert W.; Bass, Joseph J.; Carson, Brian P.; Norton, Catherine; Kozior, Marta; Wilkinson, Daniel J.; Brook, Matthew S.; Atherton, Philip J.; Smith, Ken; Jakeman, Philip M. (MDPI, 2020)

  Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). ...
• Management of staphylococcus aureus bacteraemia (SAB) in the oncology patient: further evidence supports prompt removal of central venous catheters and shorter duration of intravenous antimicrobial therapy 

  Dunne, Colum P.; Ryan, Phelim; Connolly, Roisin; Dunne, Suzanne S.; Kaballo, Mohammed A.; Powell, James; Woulfe, Bernie; O'Connell, Nuala H.; Gupta, Rajnish Kumar (Elsevier, 2020)

  Background Staphylococcus aureus bacteraemia (SAB) is associated with relatively high risk of complications and high levels of mortality. Internationally, SAB management guidelines lack consensus and especially so regarding ...

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