• Attention! A good bedside test for delirium? 

  O'Regan, Niamh A.; Ryan, Daniel J.; Boland, Eve; Connolly, Warren; McGlade, Ciara; Leonard, Maeve; Clare, Josie; Eustace, Joseph A.; Meagher, David; Timmons, Suzanne (2014)

  Background Routine delirium screening could improve delirium detection, but it remains unclear as to which screening tool is most suitable. We tested the diagnostic accuracy of the following screening methods (either ...
• A comparison of the usage of anal verge and dentate line in measuring distances within the rectum 

  Chang, K.H.; Johnson, J.H.; Waldron, David; Condon, E.T.; El-Bassiouni, M.; Coffey, Calvin J. (Elsevier, 2015)

  Introduction: The anal verge is key in determining measurement-based suitability for neoadjuvant radiotherapy in rectal cancer. The dentate line is a distinct anatomic landmark and may permit more accurate measurement ...
• Sex differences in the temporal recovery of neuromuscular function following resistance training in resistance trained men and women 18 to 35 Years 

  Davies, Robert W.; Carson, Brian P.; Jakeman, Philip M. (Frontiers Media, 2018)

  To investigate sex differences in the temporal recovery of neuromuscular function following resistance training (RT), eleven men and eight women 18–35 years completed a single RT bout (barbell back-squats, 80 % 1RM, 5 sets ...
• Detecting delirium superimposed on dementia: evaluation of the diagnostic performance of the Richmond agitation and sedation scale 

  Morandi, Alessandro; Han, Jin H.; Meagher, David; Vasilevskis, Eduard; Cerejeira, Joaquim; Hasemann, Wolfgang; MacLullich, Alasdair M.; Annoni, Giorgio; Trabucchi, Marco T.; Bellelli, Giuseppe (Elsevier, 2016)

  Objectives—Delirium disproportionately affects patients with dementia and is associated with adverse outcomes. The diagnosis of delirium superimposed on dementia (DSD), however, can be challenging due to several factors ...
• The diagnosis of delirium superimposed on dementia: an emerging challenge 

  Morandi, Alessandro; Davis, Daniel H.J.; Bellelli, Giuseppe; Arora, Rakesh C.; Caplan, Gideon A.; Kamholz, Barbara; Kolanowski, Ann; Fick, Donna Marie; Kreisel, Stefan; MacLullich, Alasdair M.; Meagher, David; Neufel, Karen; Pandharipande, Pratik P.; Richardson, Sarah; Slooter, Arjen J.C.; Taylor, John P.; Thomas, Christine; Tieges, Zoë; Teodorczuk, Andrew; Voyer, Philippe; Rudolph, James L. (Elsevier, 2017)

  Delirium occurring in patients with dementia is referred to as delirium superimposed on dementia (DSD). People who are older with dementia and who are institutionalized are at increased risk of developing delirium when ...
• Delirium and depression: inter-relationship and overlap in elderly people 

  O'Sullivan, Roisin; Inouye, Sharon K.; Meagher, David (Elsevier, 2014)

  Delirium and depression are complex neuropsychiatric syndromes that are common in the elderly and associated with a variety of poor healthcare outcomes. Accurate detection is key to providing optimal care for these conditions ...
• The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis 

  Kiernan, Miranda G.; Coffey, Calvin J.; McDermott, Kieran W.; Cotter, Paul D.; Cabrera-Rubio, Raul; Kiely, Patrick A.; Dunne, Colum P. (Oxford University Press, 2018)

  Background and Aims: Mesenteric lymph nodes are sites in which translocated bacteria incite and progress immunological responses. For this reason, understanding the microbiome of mesenteric lymph nodes in inflammatory ...
• Acute reduction of lower-body contractile function following a microbiopsy of m. vastus lateralis 

  Davies, Robert W.; Carson, Brian P.; Bass, Joseph J.; Holohan, Sorcha; Jakeman, Philip M. (Wiley and Sons Ltd, 2018)

  Twenty‐three resistance trained men 18‐35 years (23 [3] years, 1.8 [0.1] m, 81 [10] kg body mass, 2.3 [1.1] years resistance training experience; mean [SD]) performed repeated maximal voluntary isometric squats (ISQ) and ...
• Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a mouse model of oestrogen deficiency 

  Caraher, Clare; Sophocleous, Antonia; Beattie, Renwick J.; O'Driscoll, Olive M.; Cummins, Niamh M.; Brennan, Orlaith; O'Brien, Fergal J.; Ralston, Stuart H.; Bell, Steven E.J.; Towler, Mark; Idris, Aymen I. (Elsevier, 2018)

  Osteoporosis is a common disease characterised by reduced bone mass and an increased risk of fragility fractures. Low bone mineral density is known to significantly increase the risk of osteoporotic fractures, however, the ...
• Specialised cleaning associated with antimicrobial coatings for reduction of hospital acquired infection. Opinion of the COST Action Network AMiCI (CA15114) 

  Dunne, Suzanne S.; Ahonen, Merja; Modic, Martina; Crijns, Francy R.L.; Keinänen-Toivola, Minna M.; Meinke, Ruth; Keevil, William C.; Gray, Jim; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2018)

  Recognized issues with poor hand hygiene compliance among healthcare workers and reports of recontamination of previously chemically disinfected surfaces through hand contact emphasize the need for novel hygiene methods ...
• Defining the mesentery as a new organ and what this means for understanding its roles in digestive disorders 

  O'Leary, Peter D.; Coffey, Calvin J. (Taylor and Francis, 2017)

  Categorisation of structures into tissues, organs and systems is arbitrary but has considerable utility as it provides a structural hierarchy within which one can more easily investigate and better understand human biology ...
• Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds 

  Puri, Basant K.; Egan, Mary; Wallis, Fintan; Jakeman, Philip M. (Baishideng Publishing Group, 2018)

  AIM To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds (Cho). METHODS Two consecutive scans were carried out ...
• Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis/encephalitis (ME) 

  O'Sullivan, Donnchadh; Linnane, Barry; Mostyn, Amanda; Jonathan, Nteimam; Lenihan, Marie; O'Connell, Nuala H.; Dunne, Colum P. (BioMed Central, 2018)

  Background: Neisseria meningitidis is associated with meningitis and septicemia. Septic meningococcal arthritis is relatively uncommon and its diagnosis associated with clinical and microbiological challenges. Early ...
• A comparative study of hand hygiene, including alcohol-based hand rub use, among Irish medical and nursing students. 

  Kingston, Liz M.; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2018)

  Background: In Ireland, the setting for this study, the national prevalence rate of health careassociated infection (HCAI) in acute-care facilities is 5.2%. Hand hygiene and in particular hand rubbing using alcohol-based ...
• Clustered interventions to reduce inappropriate duplicate laboratory tests in an Irish tertiary hospital. 

  Brady, Hugh; Piggott, Laura; Dunne, Suzanne S.; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2018)

  Background There is increasing emphasis on understanding the rate, and avoidable costs, of inappropriate laboratory testing in hospitals, especially associated with duplication of tests following transfer of patients ...
• The effect of whey protein supplementation on the temporal recovery of muscle function following resistance training: a systematic review and meta‐analysis 

  Davies, Robert W.; Carson, Brian P.; Jakeman, Philip M. (MDPI, 2018)

  Whey protein (WP) is a widely consumed nutritional supplement, known to enhance strength and muscle mass during resistance training (RT) regimens. Muscle protein anabolism is acutely elevated following RT, which is further ...
• Anti-microbial coating innovations to prevent infectious diseases (AMiCI): cost action ca15114 

  Dunne, Colum P.; Keinanen-Toivola, Minna M.; Kahru, Anne; Teunissen, Birgit; Olmez, Hulya; Gouveia, Isabel; Melo, Luis; Murzyn, Kazimierz; Modic, Martina; Ahonen, Merja; Askew, Pete; Papadopoulos, Theofilos; Adlhart, Christian; Crijns, Francy R.L. (Taylor & Francis, 2017)

  Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European Hospitals on any given day. This represents not only public health risk, but also ...
• Isolation and gene expression profiling of intestinal epithelial cells: crypt isolation by calcium chelation from in vivo samples 

  Balfe, Aine; Lennon, Grainne; Lavelle, Aonghus; Docherty, Neil G.; Coffey, Calvin J.; Sheahan, Kieran; Winter, Desmond C.; O'Connell, Ronan P. (Dove Medical Press, 2018)

  Aim: The epithelial layer within the colon represents a physical barrier between the luminal contents and its underlying mucosa. It plays a pivotal role in mucosal homeostasis, and both tolerance and anti-pathogenic immune ...
• Adipocyte-epithelial interactions and crohn's disease - an emerging drug target 

  Coffey, Calvin J.; Kiernan, Miranda G. (Elsevier, 2017)

  Crohn's disease is hallmarked by mesenteric abnormalities including thickening, shortening and extension ofmesenteric fat over the intestinal surface (“fat wrapping” or “creeping fat”) (Coffey et al., 2016; Peyrin-Biroulet ...
• Raman spectroscopic analysis of fingernail clippings can help differentiate between postmenopausal women who have and have not suffered a fracture 

  Beattie, James R.; Cummins, Niamh M.; Caraher, Clare; O'Driscoll, Olive M.; Bansal, Aruna T.; Eastell, Richard; Ralston, Stuart H.; Stone, Michael D.; Pearson, Gill; Towler, M.R. (Libertas Academica, 2016)

  Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm ...

View more