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Gut microbiota, fusobacteria, and colorectal cancer

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dc.contributor.author Kelly, Dervla
dc.contributor.author Yang, Liying
dc.contributor.author Pei, Zhiheng
dc.date.accessioned 2019-01-15T09:24:18Z
dc.date.available 2019-01-15T09:24:18Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7472
dc.description peer-reviewed en_US
dc.description.abstract The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the entire alimentary tract (5). Recently, the concept that a normal bacterial microbiota is essential for the development of inflammation-induced carcinoma has emerged from studies of well-known colonic bacterial microbiota. This review explores the evidence for a role of fusobacteria, an anaerobic gram-negative bacterium that has repeatedly been detected at colorectal tumor sites in higher abundance than surrounding histologically normal tissue. Mechanistic studies provide insight on the interplay between fusobacteria, other gut microbiota, barrier functions, and host responses. Studies have shown that fusobacteria activate host inflammatory responses designed to protect against pathogens that promote tumor growth. We discuss how future research identifying the pathophysiology underlying fusobacteria colon colonization during colorectal cancer may lead to new therapeutic targets for cancer. Furthermore, disease-protective strategies suppressing tumor development by targeting the local tumor environment via bacteria represent another exciting avenue for researchers and are highlighted in this review. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Diseases;6, 109
dc.relation.uri http://dx.doi.org/10.3390/diseases6040109
dc.subject fusobacteria en_US
dc.subject colorectal cancer en_US
dc.subject carcinogenesis en_US
dc.subject microbiome en_US
dc.title Gut microbiota, fusobacteria, and colorectal cancer en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/diseases6040109
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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