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Analysis of vitamin K status, and its correlation with inflammation and cognition, in a well-phenotyped cohort of older Irish people

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Show simple item record Kiely, Annemarie O'Connor, Eibhlís M. 2019-01-09T08:55:58Z 2019-01-09T08:55:58Z 2014
dc.description peer-reviewed en_US
dc.description.abstract Historically, vitamin K is known for its role in blood clotting; however in recent years additional functions have been identified including a role in sphingolipid metabolism and as an anti-inflammatory agent. Studies have shown correlations between low vitamin K status and poor cognitive function while several biomarkers of inflammation are inversely correlated with cognition. The ELDERMET cohort, a group of well characterised subjects aged ≥ 64 years, were used in this study. The aim of this study was to identify potential associations between vitamin K status and cognition as well as any correlations between biomarkers of inflammation and cognition using a subgroup of the ELDERMET cohort. In addition the study aimed to ascertain significant differences in variables across living stratification i.e. the community dwelling subjects versus those in long term care. Subjects were divided into 4 groups based on their Mini Mental State Exam (MMSE) score. Vitamin K status was determined by measuring dietary and serum phylloquinone (vitamin K) status. Percent undercarboxylated osteocalcin (% ucOC) was also measured in serum as a long-term indicator of functional vitamin K status. Biomarkers of inflammation including high sensitivity C-reactive protein (hsCRP), Interleukin 6 (IL-6), Interleukin 8 (IL-8) and Tumour Necrosis Factor alpha (TNFα) were measured. Analysis of variance (ANOVA) revealed significant differences between markers of vitamin K status and inflammation and MMSE categories. Positive correlations were found between MMSE and serum and dietary phylloquinone. Inverse correlations were found between MMSE and other variables including %ucOC, hsCRP, IL-6, IL-8 and TNFα. Similarly, significant differences were found across living stratification for biomarkers of inflammation. Analysis of covariance (ANCOVA) showed a significant difference in dietary phylloquinone intake between those with severe cognitive impairment and those with normal cognitive function, and between those with moderate cognitive impairment and normal functionality. In addition, a significant difference between IL-6, TNFα and hsCRP was found especially between those with poor cognitive function and those with normal cognitive ability. This study adds to the growing body of evidence which suggests a role for vitamin K in cognitive function. Findings from this study have the potential to help inform public health policy and dietary recommendations aimed at promoting healthy aging. en_US
dc.language.iso eng en_US
dc.publisher University of Limerick en_US
dc.subject vitamin K en_US
dc.subject anti-inflammatory agent en_US
dc.subject ELDERMET cohort en_US
dc.title Analysis of vitamin K status, and its correlation with inflammation and cognition, in a well-phenotyped cohort of older Irish people en_US
dc.type info:eu-repo/semantics/masterThesis en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.supercollection ul_theses_dissertations en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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