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Carrier particle mediated stabilization and isolation of valsartan nanoparticles

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dc.contributor.author Kumar, Ajay
dc.contributor.author Davern, Peter
dc.contributor.author Hodnett, Benjamin K.
dc.contributor.author Hudson, Sarah P.
dc.date.accessioned 2019-01-08T15:47:34Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7454
dc.description peer-reviewed en_US
dc.description.abstract Drug nanoparticles are a promising solution to the challenging issues of low dissolution rates and erratic bioavailability due to their greater surface/volume ratio. The central purpose of this study is to prepare, stabilize and isolate nanoparticles of poorly water-soluble active pharmaceutical ingredients (APIs) into a dried form with the help of clay carrier particles. Isolation of nanoparticles from suspension into the dried state is crucial to avoid the problems of aggregation and Ostwald ripening. In this study nanoparticles of the API valsartan were generated via a reverse antisolvent process at high supersaturations. Montmorillonite (MMT) and protamine functionalized montmorillonite (PA-MMT) were employed for stabilization and isolation of the valsartan (Val) nanoparticles (ca. 50 nm) into a dried form. A high dissolution rate of the resultant solid formulation at high drug loadings (up to 33.3% w/w) was achieved. The dissolution rates of the isolated valsartan nanoparticle carrier composites (dried Val-MMT nanocomposites and dried Val-PA-MMT nanocomposites) were similar to that of freshly prepared suspended valsartan nanoparticles, confirming that the high surface area of the nanoparticles is retained during the adsorption and drying processes. Differential scanning calorimetry and PXRD studies indicated that the valsartan nanoparticles were amorphous when adsorbed onto the carrier particles. The dissolution rates of the Val-MMT and Val-PA-MMT nanocomposites were maintained after 10 months’ storage which indicates that no aggregation or solid state transformation of the carrier-stabilized Val nanoparticles had occurred. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation 12/RC/2275 en_US
dc.relation.ispartofseries Colloids and Surfaces B: Biointerfaces;175, pp. 554-563
dc.relation.uri https://doi.org/10.1016/j.colsurfb.2018.12.021
dc.rights This is the author’s version of a work that was accepted for publication in Colloids and Surfaces B: Biointerfaces . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Colloids and Surfaces B: Biointerfaces, 2019, 175, pp. 554-563, https://doi.org/10.1016/j.colsurfb.2018.12.021 en_US
dc.subject reverse antisolvent precipitation en_US
dc.subject drug nanoparticles en_US
dc.subject carrier particles en_US
dc.subject isolation en_US
dc.subject dissolution rate en_US
dc.subject high loading en_US
dc.title Carrier particle mediated stabilization and isolation of valsartan nanoparticles en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.colsurfb.2018.12.021
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12/RC/2275 en_US
dc.relation.projectid 15/US-C2C/13133 en_US
dc.date.embargoEndDate 2020-12-12
dc.embargo.terms 2020-12-12 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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