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Silica modification of titania nanoparticles enhances photocatalytic production of reactive oxygen species without increasing toxicity potential in vitro

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dc.contributor.author Ortelli, Simona
dc.contributor.author Costa, Anna L.
dc.contributor.author Matteucci, Pietro
dc.contributor.author Miller, Mark R.
dc.contributor.author Blosi, Magda
dc.contributor.author Gardini, Davide
dc.contributor.author Tofail, Syed A.M.
dc.contributor.author Tran, Lang
dc.contributor.author Tonelli, Domenica
dc.contributor.author Poland, Craig A.
dc.date.accessioned 2019-01-03T16:05:31Z
dc.date.available 2019-01-03T16:05:31Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7444
dc.description peer-reviewed en_US
dc.description.abstract Titania (TiO2) nanoparticles were surfacemodified using silica and citrate to implement a ‘safe-by-design’ approach for managing potential toxicity of titania nanoparticles by controlling surface redox reactivity. DLS and zeta-potential analyses confirmed the surface modification, and electron microscopy and surface area measurements demonstrated nanoscale dimensions of the particles. Electron paramagnetic resonance (EPR) was used to determine the exogenous generation of reactive oxygen species (ROS). All the produced spray dried nanotitania lowered levels of ROS when compared to the corresponding dispersed nanotitania, suggesting that the spray drying process is an appropriate design strategy for the control of nano TiO2 ROS reactivity. The modification of nanotitania with silica and with citrate resulted in increased levels of ROS generation in exogenous measurements, including photoexcitation for 60 minutes. The dichlorodihydrofluorescein (DCFH) assay of dose-dependent production of oxidative stress, generated by pristine and modified nanotitania in macrophages and alveolar epithelial cells, found no significant change in toxicity originating from the generation of reactive oxygen species. Our findings show that there is no direct correlation between the photocatalytic activity of nanotitania and its oxidative stress-mediated potential toxicity, and it is possible to improve the former, for example adding silica as a modifying agent, without altering the cell redox equilibrium. en_US
dc.language.iso eng en_US
dc.publisher Royal Society of Chemistry en_US
dc.relation NMP4-SL-2012-280716 en_US
dc.relation.ispartofseries RSC Advances;8, pp. 40369-40377
dc.relation.uri http://dx.doi.org/10.1039/C8RA07374K
dc.subject nanoparticles en_US
dc.title Silica modification of titania nanoparticles enhances photocatalytic production of reactive oxygen species without increasing toxicity potential in vitro en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1039/C8RA07374K
dc.contributor.sponsor ERC en_US
dc.relation.projectid NMP4-SL-2012-280716 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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