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Real-world variability in the prediction of intracranial aneurysm wall shear stress: The 2015 International Aneurysm CFD Challenge

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Show simple item record Valen_Sendstad, Kristian Bergersen, Aslak W. Shimogonya, Yugi Goubergrits, Leonid Bruening, Jan Pallares, Jordi Cito, Salvatore Piskin, Senol Pekkan, Kerem Geers, Ardan J. Larrabide, Ignacio Rapaka, Saikiran Mihalef, Viorel Fu, Wenyu Qiao, Aike Jain, Kartik Roller, Sabine Mardal, Kent-Andre Kamokoti, Ramji Spirka, Thomas Ashton, Neil Revell, Alistair Aristokleous, Nicolas Houston, Graeme J Tsuji, Masanori Ishida, Fujimaro Menon, Prahlad G. Browne, Leonard D. Broderick, Stephen Shojima, Masaaki Koizumi, Satoshi Barbour, Michael Aliseda, Alberto Morales, Hernán G. Lefèvre, Thierry Hodis, Simona Al-Smadi, Yahia Tran, Justin S. Marsden, Alison L. Vaippummadhom, Sreeja Einstein, Albert G. Brown, Alistair G Debus, Kristian Niizuma, Kuniyasu Rashad, Sherif Sugiyama, Shin-Ichiro Khan, Owais M. Updegrove, Adam R. Shadden, Shawn C. Cornelissen, Bart M.W. Majoie, Charles B.L.M. Berg, Philip Saalfield, Sylvia Kono, Kenichi Steinman, David A. 2019-01-03T08:59:36Z 2019-01-03T08:59:36Z 2018
dc.description peer-reviewed en_US
dc.description.abstract Purpose—Image-based computational fluid dynamics (CFD) is widely used to predict intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture risk assessment. Nevertheless, concern has been expressed over the variability of predicted WSS and inconsistent associations with rupture. Previous challenges, and studies from individual groups, have focused on individual aspects of the image-based CFD pipeline. The aim of this Challenge was to quantify the total variability of the whole pipeline. Methods—3D rotational angiography image volumes of five middle cerebral artery aneurysms were provided to participants, who were free to choose their segmentation methods, boundary conditions, and CFD solver and settings. Participants were asked to fill out a questionnaire about their solution strategies and experience with aneurysm CFD, and provide surface distributions of WSS magnitude, from which we objectively derived a variety of hemodynamic parameters. Results—A total of 28 datasets were submitted, from 26 teams with varying levels of self-assessed experience. Wide variability of segmentations, CFD model extents, and inflow rates resulted in interquartile ranges of sac average WSS up to 56%, which reduced to < 30% after normalizing by parent artery WSS. Sac-maximum WSS and low shear area were more variable, while rank-ordering of cases by low or high shear showed only modest consensus among teams. Experience was not a significant predictor of variability. Conclusions—Wide variability exists in the prediction of intracranial aneurysm WSS. While segmentation and CFD solver techniques may be difficult to standardize across groups, our findings suggest that some of the variability in image-based CFD could be reduced by establishing guidelines for model extents, inflow rates, and blood properties, and by encouraging the reporting of normalized hemodynamic parameters. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Cardiovascular Engineering and Technology;9 (4), pp. 544-564
dc.subject intracranial aneurysm en_US
dc.subject patient-specific modelling en_US
dc.subject wall shear stress en_US
dc.subject rupture risk en_US
dc.subject uncertainty quantification. en_US
dc.title Real-world variability in the prediction of intracranial aneurysm wall shear stress: The 2015 International Aneurysm CFD Challenge en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1007/s13239-018-00374-2
dc.contributor.sponsor Norges Forskningsrad en_US
dc.contributor.sponsor Heart and Stroke Foundation of Canada en_US
dc.relation.projectid 179578 en_US
dc.relation.projectid 203489/O30 en_US
dc.relation.projectid 262827 en_US
dc.relation.projectid MC7455 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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