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Effect of lignin as natural polymer on the release rate of acetylsalicylic acid tablets

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dc.contributor.author Pishnamazi, Mahboubeh
dc.contributor.author Iqbal, Javed
dc.contributor.author Shirazian, Saeed
dc.contributor.author Walker, Gavin M.
dc.contributor.author Collins, Maurice N.
dc.date.accessioned 2018-12-17T09:55:28Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7417
dc.description peer-reviewed en_US
dc.description.abstract The main focus of this paper is on the improvement of formulations utilising non-conventional bio-based excipients to improve tablet release rates. Two different formulations were considered. The first formulation contains Alcell lignin, lactose monohydrate and microcrystalline cellulose as excipients and acetylsalicylic acid (aspirin) as active pharmaceutical ingredient (API). The second formulation contains lactose monohydrate and microcrystalline cellulose as excipients and aspirin as API. The prepared formulations were roller compacted followed by milling, sieving, and tableting. The tablets were then characterised in terms of dissolution rate in order to compare the release rates. Results indicated that tablets containing Alcell lignin have quicker release, faster disintegration times and higher tablet hardness for all samples with differing process parameters. Higher API dissolution has been attributed to the amorphous structure of lignin and its interaction with aspirin, which increases dissolution of the API. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation 14SP2750 en_US
dc.relation.ispartofseries International Journal of Biological Macromolecules;124, pp. 354-359
dc.relation.uri https://doi.org/10.1016/j.ijbiomac.2018.11.136
dc.rights This is the author’s version of a work that was accepted for publication in . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Biological Macromolecules,https://doi.org/10.1016/j.ijbiomac.2018.11.136 en_US
dc.subject lignin en_US
dc.subject dry granulation en_US
dc.subject roll compaction en_US
dc.subject drug dissolution en_US
dc.subject drug release en_US
dc.subject hydrolysation en_US
dc.subject acetylsalicylic acid en_US
dc.title Effect of lignin as natural polymer on the release rate of acetylsalicylic acid tablets en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.ijbiomac.2018.11.136
dc.contributor.sponsor SFI en_US
dc.relation.projectid 14/SP/2750 en_US
dc.date.embargoEndDate 2019-11-15
dc.embargo.terms 2019-11-15 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2870380


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