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Crystal rowth of salicylamide in organic solvents

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dc.contributor.author Lynch, Aisling
dc.contributor.author Jia, Lijun
dc.contributor.author Svärd, Michael
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2018-12-13T12:44:06Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7413
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 1/11/2019
dc.description.abstract Salicylamide was used as a model active pharmaceutical compound to investigate the crystal growth process and its associated kinetics. The impact of organic solvent, supersaturation, and temperature on the crystal growth was studied. The multiparticle crystal growth kinetics were determined using the seeded isothermal de-supersaturation method and modeled using several growth rate equations, using different representations of the driving force. The results showed that crystal growth is significantly influenced by experimental conditions. Within the range of experimental conditions, the growth kinetics was affected strongly by the temperature and to a lesser degree by solvent choice. Comparison of the growth order parameter reveals a surface integration controlled growth. Higher than expected activation energies indicate desolvation as a governing process. A comparison of the influence of the solvent on the crystal growth of salicylamide against previously published approximate data at much higher supersaturation shows good agreement, but the influence on the interfacial energy is opposite to that observed for crystal nucleation. In a detailed comparison with crystal growth data of salicylic acid, there is a consistency in the influence of the solvent on the crystal growth of the two compounds. Salicylamide growth kinetics is more strongly affected by increasing temperature than salicylic acid. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 12RC2275 en_US
dc.relation.ispartofseries Crystal Growth and Design;18 (12), pp. 7305-7315
dc.relation.uri http://dx.doi.org/10.1021/acs.cgd.8b00767
dc.rights © 2018 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.8b00767 en_US
dc.subject salicylamide en_US
dc.subject crystallization en_US
dc.title Crystal rowth of salicylamide in organic solvents en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acs.cgd.8b00767
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12/RC/2275 en_US
dc.date.embargoEndDate 2019-11-01
dc.embargo.terms 2019-11-01 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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