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In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds

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dc.contributor.author Sioriki, Eleni
dc.contributor.author Lordan, Ronan
dc.contributor.author Nahra, Fady
dc.contributor.author Van Hecke, Kristof
dc.contributor.author Zabetakis, Ioannis
dc.contributor.author Nolan, Steven P.
dc.date.accessioned 2018-12-13T12:01:55Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7412
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 27/11/2019
dc.description.abstract The anti‐atherogenic (anti‐inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N‐heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet‐activating factor (PAF)‐induced platelet aggregation was probed. All complexes were found to possess anti‐aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti‐inflammatory drugs. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries ChemMedChem;13 (23), pp. 2484-2487
dc.relation.uri https://doi.org/10.1002/cmdc.201800601
dc.rights This is the peer reviewed version of the following article :ChemMedChem 2018 13 (23), pp. 2484-2487 In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds Sioriki, Eleni, Lordan, Ronan, Nahra, Fady, Van Hecke, Kristof, Zabetakis, Ioannis, Nolan, Steven P. which has been published in final form at;https://doi.org/10.1002/cmdc.201800601 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms
dc.subject platelet-activating factor en_US
dc.subject N-heterocyclic carbene en_US
dc.subject aurate en_US
dc.subject atheromatosis en_US
dc.subject anti-atherogenic en_US
dc.title In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/cmdc.201800601
dc.contributor.sponsor King Abdullah University of Science and Technology en_US
dc.relation.projectid No.OSR-2015-CCF-1974-03 en_US
dc.date.embargoEndDate 2019-11-27
dc.embargo.terms 2019-11-27 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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