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Vitamin K status and inflammation are associated with cognition in older Irish adults

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dc.contributor.author Kiely, Annemarie
dc.contributor.author Ferland, Guylaine
dc.contributor.author Ouliass, Bouchra
dc.contributor.author O'Toole, Paul W.
dc.contributor.author Purtill, Helen
dc.contributor.author O'Connor, Eibhlís M.
dc.date.accessioned 2018-12-11T15:11:43Z
dc.date.available 2018-12-11T15:11:43Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7406
dc.description peer-reviewed en_US
dc.description.abstract Studies have shown associations between reduced vitamin K status and poor cognitive function. However, despite this apparent link, direct studies measuring cognitive function, vitamin K status and inflammation are lacking. In the current study, The ELDERMET cohort was investigated to identify associations between cognition, vitamin K status and inflammation. The primary aim of the ELDERMET study was to investigate the relationship between gut bacteria, diet, lifestyle and health in 500 older Irish adults. Significant differences in serum phylloquinone, dietary phylloquinone and inflammatory markers were found across varying levels of cognitive function, after controlling for sex, age, body mass index (BMI), triglycerides and blood pressure. In addition, significantly higher levels of dietary phylloquinone were found in those with better cognition compared to those with the poorest function. Higher levels of inflammatory were also associated with poor cognition. Furthermore, both dietary and serum phylloquinone were significant independent predictors of good cognitive function, after controlling for confounders. This study highlights the importance of dietary vitamin K as a potentially protective cognitive factor; it also provides evidence for the correlation between cognition and inflammation. Strategies should be devised by which elderly populations can access rich dietary sources of phylloquinone to maintain cognition. en_US
dc.language.iso eng en_US
dc.publisher Taylor and Francis Ltd en_US
dc.relation 12RC2273 en_US
dc.relation.ispartofseries Nutritional Neuroscience; 23 (8), pp. 591-599
dc.subject vitamin K en_US
dc.subject inflammation en_US
dc.subject cognitive function en_US
dc.subject elderly en_US
dc.title Vitamin K status and inflammation are associated with cognition in older Irish adults en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1080/1028415X.2018.1536411
dc.contributor.sponsor Allen Foundation Inc.Michigan, USA en_US
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Department of Agriculture, Food and the Marine en_US
dc.relation.projectid 07/FHRI/UCC/3 en_US
dc.relation.projectid 12/RC/2273 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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