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Invited Review: Effect of early-life nutrition on the molecular and physiological regulation of puberty onset in the bull

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dc.contributor.author Kenny, D.A.
dc.contributor.author Keogh, K.
dc.contributor.author Byrne, Colin J.
dc.date.accessioned 2018-12-10T15:06:02Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7404
dc.description peer-reviewed en_US
dc.description.abstract The advent of genomic selection has accentuated interest in procuring saleable semen from young genetically elite bulls as early in life as possible. However, the timing of availability of semen for commercial use will be determined by the age at which these young animals reach puberty and subsequent sexual maturity. Enhancing early-life nutrition stimulates the functionality of the hypothalamic–pituitary–testicular axis, mediated through complex biochemical interplay between metabolic and neuroendocrine signals and culminating in enhanced testicular growth, steroidogenesis, spermatogenesis, and ultimately, earlier onset of sexual maturation. Indeed, recent evidence indicates that the timing of sexual precocity, which is dictated by an early gonadotropin rise (8–20 wk of age) in the bull, is determined by prevailing metabolic status during calfhood and is not compensable even where prior undernutrition is followed by dietary augmentation. However, despite this, the precise neuronal mechanisms regulating these developmental processes remain to be elucidated for the bull. Although early-life nutrition clearly affects the sexual maturation process, there is little evidence for latent effects on postpubertal semen characteristics. Equally, postpubertal fertility, measured as in vitro fertilization and early embryogenesis, is not influenced by nutritional status during early life. Current efforts employing high throughput nucleic acid and proteomic sequencing and targeted immunofluorescence coupled with systems biology–based gene network analyses can provide further insight on how nutrition may mediate the biochemical interaction between neuroendocrine and testicular cellular processes. Such information can be harnessed to identify potential genomic targets as part of genomically assisted breeding programs as well as facilitate development of strategic nutritional regimens to optimize sexual maturation and subsequent semen availability from genetically elite young bulls. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation 16IA4474 en_US
dc.relation.ispartofseries The Professional Animal Scientist;34 (6), pp. 533-543
dc.relation.uri https://doi.org/10.15232/pas.2018-01788
dc.rights This is the author’s version of a work that was accepted for publication in The Professional Animal Scientist . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Professional Animal Scientist, 2018, 34 (6), pp. 533-543, http://dx.doi.org/10.15232/pas.2018-01788 en_US
dc.subject nutrition en_US
dc.subject metabolic status en_US
dc.subject RNAseq en_US
dc.subject bull en_US
dc.subject puberty en_US
dc.subject sexual maturation en_US
dc.title Invited Review: Effect of early-life nutrition on the molecular and physiological regulation of puberty onset in the bull en_US
dc.type info:eu-repo/semantics/contributionToPeriodical en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.15232/pas.2018-01788
dc.contributor.sponsor Irish Department of Agriculture, Food and the Marine en_US
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid 11/S/116 en_US
dc.relation.projectid GOIPG/2013/1391 en_US
dc.relation.projectid 16/IA/4474 en_US
dc.date.embargoEndDate 2019-11-24
dc.embargo.terms 2019-11-24 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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