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Techno-economic assessment of the use of solvents in the scale-up of microbial sesquiterpene production for fuels and fine chemicals

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dc.contributor.author Pedraza-de la Cuesta, Susana
dc.contributor.author Knopper, Loes
dc.contributor.author van der Wielen, Luuk A.M.
dc.contributor.author Cuellar, Maria C.
dc.date.accessioned 2018-12-05T12:28:16Z
dc.date.available 2018-12-05T12:28:16Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7392
dc.description peer-reviewed en_US
dc.description.abstract Sesquiterpenes are a group of versatile, 15-carbon molecules with applications ranging from fuels to fine chemicals and pharmaceuticals. When produced by microbial fermentation at laboratory scale, solvents are often employed for reducing product evaporation and enhancing recovery. However, it is not clear whether this approach constitutes a favorable techno-economic alternative at production scale. In this study empirical correlations, mass transfer and process flow sheeting models were used to perform a techno-economic assessment of solvent-based processes at scales typical for flavors and fragrances (25 MT year−1) and the fuel market (25 000 MT year−1). Different solvent-based process options were compared to the current state of the art, which employs surfactants for product recovery. The use of solvents did reduce the sesquiterpene evaporation rate during fermentation and improved product recovery but it resulted in costs that were higher than, or similar to, the base case due to the additional equipment cost for solvent-product separation. However, when selecting solvents compatible with the final product formulation (e.g. in a kerosene enrichment process), unit costs as low as $0.7 kg−1 can be achieved while decreasing environmental impact. en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.relation.ispartofseries Biofpr Journal;10.1002
dc.relation.uri http://dx.doi.org/10.1002/bbb
dc.subject microbial biofuels en_US
dc.subject fine chemicals en_US
dc.subject bioprocess integration en_US
dc.subject fermentation en_US
dc.subject product recovery en_US
dc.subject techno-economic performance en_US
dc.subject emulsion en_US
dc.title Techno-economic assessment of the use of solvents in the scale-up of microbial sesquiterpene production for fuels and fine chemicals en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/bbb
dc.contributor.sponsor Dutch Ministry of Economic Affairs en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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