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Metabolic engineering of the model photoautotrophic cyanobacterium synechocystis for ethanol production: optimization strategies and challenges

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dc.contributor.author Pembroke, Tony J.
dc.contributor.author Armshaw, Patricia
dc.contributor.author Ryan, Michael P.
dc.date.accessioned 2018-11-30T10:35:05Z
dc.date.available 2018-11-30T10:35:05Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7372
dc.description peer-reviewed en_US
dc.description.abstract Photoautotrophic ethanol production using model cyanobacteria is an attractive technology that offers potential for sustainable ethanol production as a biofuel. Model strains of Synechocystis PCC6803 have been metabolically engineered to convert central metabolic intermediates such as pyruvate to acetaldehyde via cloned heterologous pyruvate decarboxylase and from acetaldehyde to ethanol via cloned homologous or heterologous alcohol dehydrogenase. While the technology is now proven, strategies are required to increase the ethanol levels through metabolic and genetic engineering and in addition, production and process strategies are required to make the process sustainable. Here we discuss both genetic and molecular strategies in combination with do wnstream strategies that are being applied while also discussing challenges to future application. en_US
dc.language.iso eng en_US
dc.publisher IntechOpen en_US
dc.relation.ispartofseries Fuel Ethanol Production from Sugarcane;
dc.relation.uri http://dx.doi.org/10.5772/intechopen.77271
dc.subject synechocystis en_US
dc.subject ethanol metabolic engineering en_US
dc.subject challenges industrial production en_US
dc.title Metabolic engineering of the model photoautotrophic cyanobacterium synechocystis for ethanol production: optimization strategies and challenges en_US
dc.type info:eu-repo/semantics/bookPart en_US
dc.identifier.doi 10.5772/intechopen.77271
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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