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Effect of early calf-hood nutrition on the transcriptional regulation of the hypothalamic-pituitary-testicular axis in Holstein-Friesian bull calves

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dc.contributor.author English, Anne-Marie
dc.contributor.author Byrne, C.J.
dc.contributor.author Cormican, Paul
dc.contributor.author Waters, Sinéad M.
dc.contributor.author Fair, Seán
dc.contributor.author Kenny, D.A.
dc.date.accessioned 2018-11-27T09:38:57Z
dc.date.available 2018-11-27T09:38:57Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7355
dc.description peer-reviewed en_US
dc.description.abstract The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesianbulls. Holstein-Friesian bull calves with a mean (±S.D.) age and bodyweight of 19 (±8.2) days and47.5 (±5.3) kg, respectively, were offered a high (n = 10) or low (n = 10) plane of nutrition in order to achieve an overall growth rate of 1.2 and 0.5 kg/day. At 126 (±3) days of age, calves were euthanized, hypothalamus (arcuate region), anterior pituitary and testicular parenchyma samples were harvested and RNAseq analysis was performed. There were 0, 49 and 1,346 genes differentially expressed in the arcuate nucleus, anterior pituitary and testicular tissue of bull calves on the low relative to the high plane of nutrition, respectively (P < 0.05; False Discovery Rate <0.05). Cell cycle processes in the anterior pituitary were down regulated in the low relative to the high plane of nutrition; there was no differential expression of genes related to reproductive processes. Gene expression involved in cholesterol and androgen biosynthesis in the testes were down regulated in animals on the low plane of nutrition. This study provides insight into the effect of early life plane of nutrition on the regulation of the HPT axis. en_US
dc.language.iso eng en_US
dc.publisher Nature Research en_US
dc.relation GOIPG/2013/1391 en_US
dc.relation.ispartofseries Scientific Reports;8:16577
dc.relation.uri http://dx.doi.org/10.1038/s41598-018-34611-4
dc.subject early calf-hood nutrition en_US
dc.subject transcriptional regulation en_US
dc.subject hypothalamic-pituitary-testicular axis en_US
dc.subject holstein-friesian bull calves en_US
dc.title Effect of early calf-hood nutrition on the transcriptional regulation of the hypothalamic-pituitary-testicular axis in Holstein-Friesian bull calves en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s41598-018-34611-4
dc.contributor.sponsor Irish Department of Agriculture, Food and the Marine en_US
dc.contributor.sponsor IRC en_US
dc.relation.projectid 11/S/116 en_US
dc.relation.projectid GOIPG/2013/1391 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2868000


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