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Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial)

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dc.contributor.author Fetterplace, Kate
dc.contributor.author Deane, Adam M.
dc.contributor.author Tierney, Audrey C.
dc.contributor.author Beach, Lisa
dc.contributor.author Knight, Laura D.
dc.contributor.author Rechnitzer, Thomas
dc.contributor.author Forsyth, Adrienne
dc.contributor.author Mourtzakis, Marina
dc.contributor.author Presneill, Jeffrey
dc.contributor.author MacIsaac, Christopher
dc.date.accessioned 2018-11-13T15:55:32Z
dc.date.available 2018-11-13T15:55:32Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7304
dc.description peer-reviewed en_US
dc.description.abstract Background: Current guidelines for the provision of protein for critically ill patients are based on incomplete evidence, due to limited data from randomised controlled trials. The present pilot randomised controlled trial is part of a program of work to expand knowledge about the clinical effects of protein delivery to critically ill patients. The primary aim of this pilot study is to determine whether an enteral feeding protocol using a volume target, with additional protein supplementation, delivers a greater amount of protein and energy to mechanically ventilated critically ill patients than a standard nutrition protocol. The secondary aims are to evaluate the potential effects of this feeding strategy on muscle mass and other patient-centred outcomes. Methods: This prospective, single-centred, pilot, randomised control trial will include 60 participants who are mechanically ventilated and can be enterally fed. Following informed consent, the participants receiving enteral nutrition in the intensive care unit (ICU) will be allocated using a randomisation algorithm in a 1:1 ratio to the intervention (high-protein daily volume-based feeding protocol, providing 25 kcal/kg and 1.5 g/kg protein) or standard care (hourly rate-based feeding protocol providing 25 kcal/kg and 1 g/kg protein). The co-primary outcomes are the average daily protein and energy delivered to the end of day 15 following randomisation. The secondary outcomes include change in quadriceps muscle layer thickness (QMLT) from baseline (prior to randomisation) to ICU discharge and other nutritional and patient-centred outcomes. Discussion: This trial aims to examine whether a volume-based feeding protocol with supplemental protein increases protein and energy delivery. The potential effect of such increases on muscle mass loss will be explored. These outcomes will assist in formulating larger randomised control trials to assess mortality and morbidity. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN: 12615000876594 UTN: U1111-1172-8563. en_US
dc.language.iso eng en_US
dc.publisher BMC en_US
dc.relation.ispartofseries Pilot and Feasibility Studies;4:52
dc.relation.uri https://doi.org/10.1186/s40814-018-0249-9
dc.subject nutritional support en_US
dc.subject enteral nutrition en_US
dc.subject nutritional requirements en_US
dc.subject dietary protein en_US
dc.subject critical illness en_US
dc.subject critical care en_US
dc.subject intensive care en_US
dc.title Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial) en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/s40814-018-0249-9
dc.contributor.sponsor Melbourne Health en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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