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Delirium and depression: inter-relationship and overlap in elderly people

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dc.contributor.author O'Sullivan, Roisin
dc.contributor.author Inouye, Sharon K.
dc.contributor.author Meagher, David
dc.date.accessioned 2018-11-12T11:06:12Z
dc.date.available 2018-11-12T11:06:12Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/7296
dc.description peer-reviewed en_US
dc.description.abstract Delirium and depression are complex neuropsychiatric syndromes that are common in the elderly and associated with a variety of poor healthcare outcomes. Accurate detection is key to providing optimal care for these conditions but is complicated by their considerable clinical overlap. This includes shared symptom profiles as well as comorbidity. Careful assessment of symptom character as well as the context and course of disturbances can allow for more accurate diagnosis. Prior depressive illness is a common finding in patients with delirium, while depressive illness is a recognised sequel of delirium. Evidence points to similar pathophysiological mechanisms involving disturbances in stress and inflammatory responses, monoaminergic and melatonergic functions, that in turn point to avenues for therapeutic intervention. Development of better tools for systematic assessment for delirium and depression in populations at high risk by virtue of age, diminished cognitive reserve and frailty is a key target to achieve improved healthcare outcomes. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Lancet Psychiatry;1 (4), pp. 303-311
dc.relation.uri http://dx.doi.org/:10.1016/S2215-0366(14)70281-0
dc.rights This is the author’s version of a work that was accepted for publication in The Lancet Psychiatry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Lancet Psychiatry, 1 (4), pp. 303-311, https://doi.org/10.1016/S2215-0366(14)70281-0 en_US
dc.subject delirium en_US
dc.subject depression en_US
dc.subject overlap syndrome en_US
dc.subject cognition en_US
dc.subject elderly en_US
dc.title Delirium and depression: inter-relationship and overlap in elderly people en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/S2215-0366(14)70281-0
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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