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Caffeine treatment for apnea of prematurity and the influence on dose-dependent postnatal weight gainobserved over 15 years

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dc.contributor.author Philip, Roy K.
dc.contributor.author Ismail, Abu
dc.contributor.author Murphy, Bernadette
dc.contributor.author Mirza, Adnan
dc.contributor.author Quinn, Collette
dc.contributor.author Dunworth, Margo
dc.date.accessioned 2018-10-03T09:45:35Z
dc.date.available 2018-10-03T09:45:35Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7189
dc.description peer-reviewed en_US
dc.description.abstract Background and Aim: To analyze the influence on weight gain of infants exposed to two dosage regimens of oral caffeine citrate (CC) for apnea of prematurity. Methods: Retrospective descriptive observational study of an eligible very low birth weight cohort over a 15-year period in an Irish University hospital. Data were analyzed between two distinct postnatal ages: 14–28 and 29–56 days. Results: During the 15-year study, 457 infants were prescribed caffeine. Among the 14–28-day group, after applying exclusion criteria, 418 infants qualified. Two hundred forty-eight infants received 5 mg/(kg·day) and 170 received 10 mg/(kg·day) of CC. Among the 29–56-day group, 362 infants were identified and after applying exclusions, 332 fulfilled entry criteria [214 on 5 mg/(kg·day) and 118 on 10 mg/(kg·day) regimen]. Baseline characteristics of infants were comparable between groups without statistically significant differences. Mean daily weight gain (MDWG) in grams from day 14 to 28 showed a higher rate of increase for the 5 mg/(kg·day) group compared with the 10 mg/(kg·day) group (17.2 – 12 g vs. 13.0 – 10.2 g [p = 0.04]). From day 29 to 56, also MDWG was higher among infants on 5 mg/(kg·day) of CC compared with 10 mg/(kg·day) group (15.6 – 10.8 g vs. 10.2 – 9.8 g [p = 0.011]). Conclusion: While a variety of measures are optimized to promote postnatal weight gain of premature infants close to an ideal intrauterine growth curve, not paying sufficient attention to one of the most widely used catabolic agents in neonatology is questionable and warrants vigilance. Additional nutritional measures could be offered to those with prolonged caffeine exposure. en_US
dc.language.iso eng en_US
dc.publisher Mary Ann Liebert, Inc., Publishers en_US
dc.relation.ispartofseries Journal of Caffeine and Adenosine Research;8 (3), pp. 99-106
dc.relation.uri http://dx.doi.org/10.1089/caff.2018.0005
dc.subject neonatal intensive care unit en_US
dc.subject caffeine citrate en_US
dc.subject apnea of prematurity en_US
dc.subject very low birth weight infants en_US
dc.subject methylxanthines en_US
dc.subject neonatal nutrition en_US
dc.title Caffeine treatment for apnea of prematurity and the influence on dose-dependent postnatal weight gainobserved over 15 years en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1089/caff.2018.0005
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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