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Creating cocrystals: a review of pharmaceutical cocrystal preparation routes and applications

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dc.contributor.author Karimi-Jafari, Maryam
dc.contributor.author Padrela, Luis
dc.contributor.author Walker, Gavin M.
dc.contributor.author Croker, Denise M.
dc.date.accessioned 2018-09-25T14:53:05Z
dc.date.available 2018-09-25T14:53:05Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7165
dc.description peer-reviewed en_US
dc.description.abstract Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit. Where once solubility manipulation was seen as the primary driver for cocrystal formation, cocrystals have recently been shown to provide attractive options for taste masking, mechanical property improvement, and intellectual property generation and extension. Cocrystals are becoming a commercial reality with a number of cocrystal products currently on the market and more following in registration and clinical trial phases. Increased commercialization of cocrystals has in turn necessitated additional research on methods to make cocrystals, with particular emphasis placed on emerging technologies that can offer environmentally attractive and efficient options. Methods of producing cocrystals and of harnessing the bespoke physical property adjustment provided by cocrystals are reviewed in this article, with a particular focus on emerging trends in these areas. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 12RC2275 en_US
dc.relation.ispartofseries Crystal Growth and Design; 18 (10), pp. 6370-6387
dc.relation.uri http://dx.doi.org/10.1021/acs.cgd.8b00933
dc.subject cocrystals en_US
dc.subject solid state materials en_US
dc.title Creating cocrystals: a review of pharmaceutical cocrystal preparation routes and applications en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acs.cgd.8b00933
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12/RC2/275 en_US
dc.relation.projectid 15/US-C2C/I3133 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2861349


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