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Temporal trends in acute kidney injury across health care settings in the Irish health system: a cohort study

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dc.contributor.author Stack, Austin G.
dc.contributor.author Li, Xia
dc.contributor.author Kaballo, Mohammed A. M
dc.contributor.author Elsayed, Mohamed E.
dc.contributor.author Johnson, Howard
dc.contributor.author Murray, Patrick T.
dc.contributor.author Saran, Rajiv
dc.contributor.author Browne, Leonard D.
dc.date.accessioned 2018-08-29T10:21:53Z
dc.date.available 2018-08-29T10:21:53Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/7108
dc.description peer-reviewed en_US
dc.description.abstract Background. Complete ascertainment of the true rates of acute kidney injury (AKI) and emerging trends are essential for planning of preventive strategies within health systems. Methods. We conducted a retrospective cohort study from 2005 to 2014 using data from regional laboratory information systems to determine incidence rates of AKI and severity Stages 1–3 in the Irish health system. Multivariable models were developed to explore annual trends and the contributions of demographic factors, clinical measures, geographic factors and location of medical supervision expressed as adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results. From 2005 to 2014, incidence rates of AKI increased from 6.1% (5.8–6.3) to 13.2% (12.7–13.8) per 100 patient-years in men and from 5.0% (4.8–5.2) to 11.5% (11.0–12.0) in women, P<0.001. Stage 1 AKI accounted for the greatest growth in incidence, from 4.4% (95% CI 4.3–4.6) in 2005 to 10.1% (95% CI 9.8–10.5) in 2014 (P<0.001 for trend). Compared with 2005, patients in 2014 were more likely to experience AKI [OR 4.53 (95% CI 4.02–5.1) for Stage 1, OR 5.22 (4.16–6.55) for Stage 2 and OR 4.11 (3.05–5.54) for Stage 3], adjusting for changing demographic and clinical profiles. Incidence rates of AKI increased in all locations of medical supervision during the period of observation, but were greatest for inpatient [OR 19.11 (95% CI 17.69–20.64)] and emergency room settings [OR 5.97 (95% CI 5.56–6.42)] compared with a general practice setting (referent). Conclusion. Incidence rates of AKI have increased substantially in the Irish health system, which were not accounted for by changing demographic patterns, clinical profiles or location of medical supervision. en_US
dc.language.iso eng en_US
dc.publisher Oxford University Press en_US
dc.relation.ispartofseries Nephrology Dialysis Transplantation;pp. 1-11
dc.relation.uri http://dx.doi.org/10.1093/ndt/gfy226
dc.subject acute kidney injury en_US
dc.subject acute renal failure en_US
dc.subject AKI en_US
dc.subject epidemiology en_US
dc.subject surveillance en_US
dc.title Temporal trends in acute kidney injury across health care settings in the Irish health system: a cohort study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1093/ndt/gfy226
dc.contributor.sponsor HRB en_US
dc.relation.projectid HRA-2013-PHR-437 en_US
dc.relation.projectid HRA-2014-PHR-685 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2870855


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