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An in vitro and in vivo study of the bioactive properties of milk peptides: antioxidant and dipeptidyl peptidase IV inhibitory peptides

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dc.contributor.advisor Fitzgerald, Richard J.
dc.contributor.advisor Jakeman, Philip M.
dc.contributor.author Power, Orla
dc.date.accessioned 2018-08-09T14:36:44Z
dc.date.available 2018-08-09T14:36:44Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/10344/7046
dc.description peer-reviewed en_US
dc.description.abstract The beneficial effects of food-derived antioxidant (AO) in health promotion and disease prevention are being increasingly recognised. Recently there has been a particular focus on milk-derived peptides as a source of AOs, these peptides are inactive within the sequence of the parent protein but can be released during enzyme hydrolysis. Once released, the peptides have been shown to possess radical scavenging, metal ion chelation properties and the ability to inhibit lipid peroxidation. A variety of methods have been used to evaluate in vitro AO capacity, however, there is no standardised methodology which hinders comparison of data. This review provides an overview on the generation of AO peptides from milk proteins, the proposed mechanisms of protein/peptide induced AO capacity, in vitro measurement of AO capacity, in vivo evaluation of plasma AO capacity and the bioavailability of AO peptides. The understanding gained from other food proteins is referred to where specific data on milk derived peptides is limited. The potential applications and health benefits of AO peptides are discussed with a particular focus on the aging population. The regulatory requirements for peptide-based AO functional foods are also considered. en_US
dc.language.iso eng en_US
dc.publisher University of Limerick en_US
dc.subject milk peptides en_US
dc.subject Type 2 diabetes en_US
dc.subject bioactive properties en_US
dc.title An in vitro and in vivo study of the bioactive properties of milk peptides: antioxidant and dipeptidyl peptidase IV inhibitory peptides en_US
dc.type info:eu-repo/semantics/doctoralThesis en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.supercollection ul_theses_dissertations en_US
dc.contributor.sponsor FHI en_US
dc.contributor.sponsor EI en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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