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Prospects of zinc supplementation in autism spectrum disorders and shankopathies Such as Phelan McDermid Syndrome.

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Show simple item record Hagmeyer, Simone Sauer, Ann Katrin Grabrucker, Andreas M. 2018-07-19T09:47:59Z 2018-07-19T09:47:59Z 2018
dc.identifier.issn 1663-3563
dc.description peer-reviewed en_US
dc.description.abstract The loss of one copy of SHANK3 (SH3 and multiple ankyrin repeat domains 3) in humans highly contributes to Phelan McDermid syndrome (PMDS). In addition, SHANK3 was identified as a major autism candidate gene. Interestingly, the protein encoded by the SHANK3 gene is regulated by zinc. While zinc deficiency depletes synaptic pools of Shank3, increased zinc levels were shown to promote synaptic scaffold formation. Therefore, the hypothesis arises that patients with PMDS and Autism caused by Shankopathies, having one intact copy of SHANK3 left, may benefit from zinc supplementation, as elevated zinc may drive remaining Shank3 into the post-synaptic density (PSD) and may additional recruit Shank2, a second zinc-dependent member of the SHANK gene family. Further, elevated synaptic zinc levels may modulate E/I ratios affecting other synaptic components such as NMDARs. However, several factors need to be considered in relation to zinc supplementation such as the role of Shank3 in the gastrointestinal (GI) system-the location of zinc absorption in humans. Therefore, here, we briefly discuss the prospect and impediments of zinc supplementation in disorders affecting Shank3 such as PMDS and propose a model for most efficacious supplementation. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Synaptic Neuroscience;10, article 11
dc.rights First published by Frontiers Media en_US
dc.subject Zn en_US
dc.subject autism en_US
dc.subject ASD en_US
dc.subject synapse en_US
dc.subject trace metal en_US
dc.subject 22q13 en_US
dc.title Prospects of zinc supplementation in autism spectrum disorders and shankopathies Such as Phelan McDermid Syndrome. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2018-07-19T09:41:44Z
dc.description.version PUBLISHED
dc.identifier.doi 10.3389/fnsyn.2018.00011
dc.contributor.sponsor Evangelisches Studienwerk Villigst en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2853839
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Frontiers In Synaptic Neuroscience
dc.description.status peer-reviewed

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