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Improvement in dietary inflammatory index score after 6-month dietary intervention is associated with reduction in interleukin-6 in patients with coronary heart disease: The AUSMED heart trial

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dc.contributor.author Mayr, Hannah L.
dc.contributor.author Itsiopoulos, Catherine
dc.contributor.author Tierney, Audrey C.
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Hebert, James R.
dc.contributor.author Shivappa, Nitin
dc.contributor.author Thomas, Colleen J.
dc.date.accessioned 2018-07-17T11:11:59Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6968
dc.description peer-reviewed en_US
dc.description.abstract The Dietary Inflammatory Index (DII) was designed to measure the inflammatory potential of one's diet. Evidence from observational studies supports that a higher (ie, more proinflammatory) DII score is associated with inflammation and cardiometabolic diseases. We hypothesized that reduction in DII score would improve inflammatory cytokines. To test this hypothesis, we assessed data from a dietary intervention trial in patients with diagnosed coronary heart disease (CHD) to determine whether reduction in DII scores through healthy diets is linked to improvement in inflammatory and related cardiometabolic risk markers. Participants (n = 65, 83% male) were randomized to a Mediterranean diet or low-fat diet intervention for 6-months. Anthropometry, body composition and blood markers were measured and DII scores were calculated from 7-day food diaries. After 6- months, in participants who completed the intervention (n = 56), reduction in DII score correlated significantly with reduction in high sensitivity interleukin-6 (hs-IL-6) (r = 0.34, 95% CI 0.05, 0.56) and triglycerides (r = −0.30, 95% CI -0.51, −0.06) but not with C-reactive protein, adiponectin, glucose, body composition or anthropometry. The adjusted mean difference in hs-IL-6 and triglycerides between the highest and lowest tertiles of DII improvement was −0.47 pg/mL (95% CI 0.41, 1.10) and +0.30 mmol/L (95% CI 1.06, 1.59), respectively. The present study found that improvement in DII score through healthy diet intervention was linked with reduced levels of hs-IL-6, but also increased triglycerides, in adult Australian patients with CHD. Future research is warranted to investigate the impact of change in DII on cardiometabolic risk markers in larger cohorts, other disease populations or healthy subjects and with longer-term follow up. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Nutrition Research;55, pp. 108-121
dc.relation.uri https://doi.org/10.1016/j.nutres.2018.04.007
dc.rights This is the author’s version of a work that was accepted for publication in Nutrition Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition Research, 2018, 55, pp. 108-121, https://doi.org/10.1016/j.nutres.2018.04.007 en_US
dc.subject diet en_US
dc.subject dietary inflammatory index en_US
dc.subject inflammation en_US
dc.subject cytokines en_US
dc.subject coronary disease en_US
dc.subject clinical trial en_US
dc.title Improvement in dietary inflammatory index score after 6-month dietary intervention is associated with reduction in interleukin-6 in patients with coronary heart disease: The AUSMED heart trial en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.nutres.2018.04.007
dc.contributor.sponsor La Trobe University en_US
dc.contributor.sponsor United States National Institute for Diabetes en_US
dc.relation.projectid R44DK103377 en_US
dc.date.embargoEndDate 2019-04-25
dc.embargo.terms 2019-04-25 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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