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Modelling drug release from polymer-free coronary stents with microporous surfaces

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Show simple item record Vo, Tuoi T.N. Morgan, Sarah McCormick, Christopher McGinty, Sean McKee, Sean Meere, Martin 2018-07-16T12:11:50Z 2018-07-16T12:11:50Z 2018
dc.description peer-reviewed en_US
dc.description.abstract Traditional coronary drug-eluting stents (DES) are made from metal and are coated with a permanent polymer film containing an anti-proliferative drug. Subsequent to stent deployment in a diseased coronary artery, the drug releases into the artery wall and helps prevent restenosis by inhibiting the proliferation of smooth muscle cells. Although this technology has proven to be remarkably successful, there are ongoing concerns that the presence of a polymer in the artery can lead to deleterious medical complications, such as late stent thrombosis. Polymer-free DES may help overcome such shortcomings. However, the absence of a rate-controlling polymer layer makes optimisation of the drug release profile a particular challenge. The use of microporous stent surfaces to modulate the drug release rate is an approach that has recently shown particularly promising clinical results. In this study, we develop a mathematical model to describe drug release from such stents. In particular, we develop a mathematical model to describe drug release from microporous surfaces. The model predicts a twostage release profile, with a relatively rapid initial release of most of the drug, followed by a slower release of the remaining drug. In the model, the slow release phase is accounted for by an adsorption/desorption mechanism close to the stent surface. The theoretical predictions are compared with experimental release data obtained in our laboratory, and good agreement is found. The valuable insights provided by our model will serve as a useful guide for designing the enhanced polymer-free stents of the future. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;544 pp 392-401
dc.subject polymer-free drug-eluting stent en_US
dc.subject microporous surface en_US
dc.subject mathematical model en_US
dc.subject atomic force microscopy en_US
dc.title Modelling drug release from polymer-free coronary stents with microporous surfaces en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.ijpharm.2017.12.007
dc.contributor.sponsor The Royal Society en_US
dc.contributor.sponsor EPSRC en_US
dc.contributor.sponsor MACSI en_US
dc.relation.projectid IE131240 en_US
dc.relation.projectid EP/J007242/1 en_US
dc.relation.projectid EP/J007579/1 en_US
dc.relation.projectid EP/F50036X/1 en_US
dc.relation.projectid 12/IA/1683 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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