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Characterization of adrenocortical tumors by 18F-FDG PET/CT: does steroid hormone hypersecretion status modify the uptake pattern?

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dc.contributor.author Paladino, Nunzia Cinzia
dc.contributor.author Guérin, Carole
dc.contributor.author Lowery, Aoife J.
dc.contributor.author Attard, Andrea
dc.contributor.author Essamet, Wassim
dc.contributor.author Slotema, Eveline
dc.contributor.author Morange, Isabelle
dc.contributor.author Castinetti, Frédéric
dc.contributor.author Brue, Thierry
dc.contributor.author Loundou, Anderson
dc.contributor.author Taïeb, David
dc.contributor.author Sebag, Frédéric
dc.date.accessioned 2018-05-14T14:04:53Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6838
dc.description peer-reviewed en_US
dc.description.abstract Background adrenal tumor-to-liver uptake value (Tmx:Lmx) on 18F-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses. The potential impact of steroid hormone secretion on 18F-FDG uptake is still debatable. The aim of this study was to evaluate this relationship. Methods 2010–2015: 73 patients who underwent adrenalectomy for adrenocortical tumors [49 secreting/(SA) and 24 non-secreting/(NSA)] were retrospectively included in the study. Fourteen were malignant. All patients underwent hormonal evaluation, functional and anatomical imaging, Weiss scoring and Ki 67 evaluation. Results malignant tumors exhibit higher SUVmax than benign tumors (median 7.75 vs 3.06 respectively, p < 0.001) and Tmx:Lmx was 2.7 vs 1.17 for benign tumors, p < 0.001. Tmx:Lmx was positively correlated to Weiss score (p < 0.001). No significant difference was observed for Tmx:Lmx between SA and NSA overall (p = 0.851), regardless of the subgroup of tumors analyzed. Tmx:Lmx was not correlated to tumor size (p < 0.508) or 24 h free urinary cortisol level (p < 0.522). Conclusions no correlation was observed between Tmx:Lmx and hormonal status, however the correlation between ratio, malignancy and Weiss score confirm the utility of 18F-FDG PET/CT for the differentiation of benign from malignant adrenal lesions, irrespective of the hormone secretory status of the tumor. 18F-FDG PET/CT is a useful biomarker in the diagnosis of adrenal tumors, regardless of the secretion status. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Surgical Oncology;27 (2), pp. 231-235
dc.relation.uri https://doi.org/10.1016/j.suronc.2018.04.003
dc.rights This is the author’s version of a work that was accepted for publication in Surgical Oncology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Surgical Oncology, 2018, 27 (2), pp. 231-235, https://doi.org/10.1016/j.suronc.2018.04.003 en_US
dc.subject adrenal masses en_US
dc.subject hormone secretion en_US
dc.title Characterization of adrenocortical tumors by 18F-FDG PET/CT: does steroid hormone hypersecretion status modify the uptake pattern? en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.suronc.2018.04.003
dc.date.embargoEndDate 2019-04-23
dc.embargo.terms 2019-04-23 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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