University of Limerick Institutional Repository

MitoQ loaded chitosan-hyaluronan composite membranes for wound healing

DSpace Repository

Show simple item record Tamer, M. Tamer Collins, Maurice N. Valachová, Katarina Hassan, Mohamed A. Omer, Ahmed M. Mohy-Eldin, Mohamed S. Švík, Karol Jurčík, Rastislav Ondruška, L’ubomír Biró, Csaba Albadarin, Ahmad B. Šoltés, Ladislav 2018-05-11T14:08:45Z 2018-05-11T14:08:45Z 2018
dc.description peer-reviewed en_US
dc.description.abstract Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant—MitoQ—was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Materials;11: 569
dc.subject mitochondrially-targeted antioxidant en_US
dc.subject skin wounds en_US
dc.subject hyaluronan en_US
dc.subject chitosan en_US
dc.title MitoQ loaded chitosan-hyaluronan composite membranes for wound healing en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/ma11040569
dc.relation.projectid APVV 15-0308 en_US
dc.relation.projectid VEGA 2/0065/15 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2869134

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


My Account