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MitoQ loaded chitosan-hyaluronan composite membranes for wound healing

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dc.contributor.author Tamer, M. Tamer
dc.contributor.author Collins, Maurice N.
dc.contributor.author Valachová, Katarina
dc.contributor.author Hassan, Mohamed A.
dc.contributor.author Omer, Ahmed M.
dc.contributor.author Mohy-Eldin, Mohamed S.
dc.contributor.author Švík, Karol
dc.contributor.author Jurčík, Rastislav
dc.contributor.author Ondruška, L’ubomír
dc.contributor.author Biró, Csaba
dc.contributor.author Albadarin, Ahmad B.
dc.contributor.author Šoltés, Ladislav
dc.date.accessioned 2018-05-11T14:08:45Z
dc.date.available 2018-05-11T14:08:45Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6833
dc.description peer-reviewed en_US
dc.description.abstract Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant—MitoQ—was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Materials;11: 569
dc.relation.uri http://doi.org/10.3390/ma11040569
dc.subject mitochondrially-targeted antioxidant en_US
dc.subject skin wounds en_US
dc.subject hyaluronan en_US
dc.subject chitosan en_US
dc.title MitoQ loaded chitosan-hyaluronan composite membranes for wound healing en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/ma11040569
dc.relation.projectid APVV 15-0308 en_US
dc.relation.projectid VEGA 2/0065/15 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2869134


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