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Characterisation of human urethral rupture thresholds for urinary catheter inflation related injuries

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dc.contributor.author Davis, Niall Francis
dc.contributor.author Cunnane, Eoghan M.
dc.contributor.author Mooney, Rory
dc.contributor.author Hess, J.
dc.contributor.author Walsh, Michael T.
dc.date.accessioned 2018-05-04T08:14:43Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6813
dc.description peer-reviewed en_US
dc.description.abstract Data on urethral catheter related injuries is sparse. In this study we aimed to characterise urethral diametric strain and urinary catheter inflation pressure thresholds that precede human urethral trauma during urethral catheterisation (UC). Human urethras were obtained from patients undergoing male to female gender reassignment surgery [(n = 9; age 40 ± 13.13 (range: 18–58)) years]. 12Fr urinary catheters were secured in the bulbar urethra and the catheter's anchoring balloon was inflated with a syringe pump apparatus. Urethral diametric strain and balloon pressure were characterised with video extensometry and a pressure transducer respectively. Immunohistochemistry, Masson's trichrome and Verhoeff-Van Gieson stains evaluated urethral trauma microscopically. Morphological characterisation of the urethral lumen was performed by examining non-traumatised histological sections of urethra and recording luminal area, perimeter and major/minor axis length. Tearing (n = 3) and rupture (n = 3) of the urethra were observed following catheter balloon inflation. The threshold for human urethral rupture occurred at an external urethral diametric strain ≥ 27% and balloon inflation pressure ≥ 120kPa. Significant relationships were identified between urethral wall thickness and the level of trauma induced during catheter balloon inflation (p = 0.001) and between the pressure required to inflate the catheter balloon and the length of the major axis of the urethral lumen (p = 0.004). Ruptured urethras demonstrated complete transection of collagen, elastin and muscle fibres. In conclusion, urethral rupture occurs at an external urethral diametric strain ≥ 27% or with balloon inflation pressures ≥ 120 kPa. Incorporation of these parameters may be useful for designing a safety mechanism for preventing catheter inflation related urethral injuries. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation Horizon en_US
dc.relation.ispartofseries Journal of the Mechanical Behavior of Biomedical Materials;83, pp. 102-107
dc.relation.uri https://doi.org/10.1016/j.jmbbm.2018.04.015
dc.rights This is the author’s version of a work that was accepted for publication in Journal of the Mechanical Behavior of Biomedical Materials . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in en_US
dc.subject urethral trauma en_US
dc.subject urethral injury en_US
dc.subject urinary catheter en_US
dc.subject urethral rupture en_US
dc.title Characterisation of human urethral rupture thresholds for urinary catheter inflation related injuries en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.jmbbm.2018.04.015
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor European Union (EU)
dc.contributor.sponsor Horizon 2020
dc.relation.projectid 708867 en_US
dc.date.embargoEndDate 2020-04-19
dc.embargo.terms 2020-04-19 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2868490


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