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Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions

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dc.contributor.author Davis, Mark T.
dc.contributor.author Potter, Catherine B.
dc.contributor.author Mohammadpour, Maryam
dc.contributor.author Albadarin, Ahmad B.
dc.contributor.author Walker, Gavin M.
dc.date.accessioned 2018-05-02T08:15:50Z
dc.date.issued 2017
dc.identifier.citation Mark T Davis, Catherine B Potter, Maryam Mohammadpour, Ahmad B Albadarin, Gavin M Walker (2017) 'Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions'. International Journal Of Pharmaceutics, 519 (1-2):365-372. en_US
dc.identifier.uri http://hdl.handle.net/10344/6805
dc.description peer-reviewed en_US
dc.description.abstract .A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40 °C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;519 (1-2), pp. 365-372
dc.relation.uri https://doi.org/10.1016/j.ijpharm.2017.01.043
dc.rights This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 2017, 519 (1-2), pp. 365-372,https://doi.org/10.1016/j.ijpharm.2017.01.043 en_US
dc.subject itraconazole en_US
dc.subject soluplus en_US
dc.subject HPMCP en_US
dc.subject ternary en_US
dc.subject amorphous en_US
dc.subject spray drying en_US
dc.title Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2018-05-02T08:00:39Z
dc.identifier.doi 10.1016/j.ijpharm.2017.01.043
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12/RC/2275 en_US
dc.date.embargoEndDate 2019-01-25
dc.embargo.terms 2019-01-25 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2705765
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle International Journal Of Pharmaceutics
dc.description.status peer-reviewed


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