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Solid-state transformations of sulfathiazole polymorphs: the effects of milling and humidity

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Show simple item record Hu, Yun Li, Boyan Ryder, Alan G. Erxleben, Andrea McArdle, Patrick Rasmuson, Åke C. Hodnett, Benjamin K. 2018-04-24T15:00:54Z 2018-04-24T15:00:54Z 2013
dc.description peer-reviewed en_US
dc.description.abstract The effect of milling on the solid-state transitions of sulfathiazole polymorphs in the absence and presence of solvent and excipients was monitored by X-ray powder diffraction (XRPD), attenuated total reflectance infrared (ATR-IR) and near-infrared (NIR) spectroscopy. Sulfathiazole forms FII-FV undergo a transformation toward the metastable FI, which involves an intermediate amorphous stage upon milling at ambient temperature. Milling FIII with catalytic amounts of solvent converts FIII to FIV or to mixtures of FI and FIV depending on the solvent used. Pure FIV can be easily prepared from FIII by this method. The physical stability of pure sulfathiazole forms in the presence of different levels of relative humidity (RH) was also investigated. At low RH all sulfathiazole forms are stable but at RH levels above 70% FII, FIII and FIV remain stable while FI and FV transform to mixtures of FII and FIV without any apparent change in the external form of the crystals. Co-milling FIII with a range of excipients gave results which depended on the excipient used and co-milling with cellulose gave samples which had an amorphous content that was stable at 10% RH for at least nine months at ambient temperature. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.rights © 2013 ACS This document is the author version of a Published Work that appeared in final form in Journal Title, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see en_US
dc.subject sulfathiazole en_US
dc.subject milling en_US
dc.subject polymorph transformation en_US
dc.subject stability en_US
dc.subject NIR spectroscopy en_US
dc.subject X-ray diffraction en_US
dc.subject ATR-IR spectroscopy en_US
dc.title Solid-state transformations of sulfathiazole polymorphs: the effects of milling and humidity en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/cg4002779
dc.contributor.sponsor SFI en_US
dc.relation.projectid 07/SRC/B1158 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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