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Postural control deficits in people with multiple sclerosis: A systematic review and meta-analysis

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dc.contributor.author Comber, Laura
dc.contributor.author Sosnoff, Jacob J.
dc.contributor.author Galvin, Rose
dc.contributor.author Coote, Susan
dc.date.accessioned 2018-04-16T15:39:02Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6751
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 19/2/2019
dc.description.abstract Background Multiple sclerosis (MS) is a neurological condition that can affect the postural stability of the individual and predispose falls in this population. Methods A systematic literature search identified case-control studies investigating differences in postural control across a diversity of task conditions, with the exception of gait, between people with MS and healthy controls. Meta-analysis was conducted where a variable was presented by four or more studies. Results Forty-three studies of people with a mean Expanded Disability Status Scale (EDSS) of 1.0 to 6.0 were included. Seven conditions of assessment and 105 individual measurement variables relating to postural control were included. Quiet stance was the only condition (11 studies) possessing sufficient data to contribute to meta-analysis in terms of centre of pressure path length (SMD = 1.04, 95% CI {0.86–1.22}, p < 0.001), medio-lateral velocity (SMD = 1.35, 95% CI {0.77–1.92}, p < 0.001) and 95% confidence ellipse (SMD = 0.83 95% CI {0.59–1.08}, p < 0.001). Results indicate that regardless of task complexity or sensory condition, people with MS display considerable deficits in postural control in comparison to healthy controls. Conclusions The large number of variables and lack of standardisation of reporting makes data synthesis challenging, however, people with MS display considerable deficits in postural control compared to healthy controls regardless of task condition or complexity en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Gait and Posture;61, pp. 445-452
dc.relation.uri https://doi.org/10.1016/j.gaitpost.2018.02.018
dc.rights This is the author’s version of a work that was accepted for publication in Gait and Posture. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Gait and Posture, 2018, 61, pp. 445-452,https://doi.org/10.1016/j.gaitpost.2018.02.018 en_US
dc.subject multiple sclerosis en_US
dc.subject accidental falls en_US
dc.subject postural balance en_US
dc.title Postural control deficits in people with multiple sclerosis: A systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.gaitpost.2018.02.018
dc.date.embargoEndDate 2019-02-19
dc.embargo.terms 2019-02-19 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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