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Gut microbiota in older subjects: variation, health consequences and dietary intervention prospects

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Show simple item record O'Connor, Eibhlís M. O'Herlihy, Eileen A. O'Toole, Paul W. 2018-04-07T13:14:15Z 2018-04-07T13:14:15Z 2014
dc.description peer-reviewed en_US
dc.description.abstract Alterations in intestinal microbiota composition and function have been linked to conditions including functional gastrointestinal disorders, obesity and diabetes. The gut microbiome encodes metabolic capability in excess of that encoded by the human genome, and bacterially produced enzymes are important for releasing nutrients from complex dietary ingredients. Previous culture-based studies had indicated that the gut microbiota of older people was different from that of younger adults, but the detailed findings were contradictory. Small-scale studies had also shown that the microbiota composition could be altered by dietary intervention or supplementation. We showed that the core microbiota and aggregate composition in 161 seniors was distinct from that of younger persons. To further investigate the reasons for this variation, we analysed the microbiota composition of 178 elderly subjects for whom the dietary intake data were available. The data revealed distinct microbiota composition groups, which overlapped with distinct dietary patterns that were governed by where people lived: at home, in rehabilitation or in long-term residential care. These diet-microbiota separations correlated with cluster analysis of NMR-derived faecal metabolites and shotgun metagenomic data. Major separations in the microbiota correlated with selected clinical measurements. It should thus be possible to programme the microbiota to enrich bacterial species and activities that promote healthier ageing. A number of other studies have investigated the effect of certain dietary components and their ability to modulate the microbiota composition to promote health. This review will discuss dietary interventions conducted thus far, especially those in elderly populations and highlight their impact on the intestinal microbiota. en_US
dc.language.iso eng en_US
dc.publisher Cambridge University Press en_US
dc.relation.ispartofseries Proceedings of the Nutrition Society;73 (4), pp. 441-451
dc.rights Material on these pages is copyright Cambridge University Press or reproduced with permission from other copyright owners. It may be downloaded and printed for personal reference, but not otherwise copied, altered in any way or transmitted to others (unless explicitly stated otherwise) without the written permission of Cambridge University Press. Hypertext links to other Web locations are for the convenience of users and do not constitute any endorsement or authorisation by Cambridge University Press. en_US
dc.subject diet en_US
dc.subject microbiota en_US
dc.subject health en_US
dc.subject irritable-bowel-syndrome en_US
dc.title Gut microbiota in older subjects: variation, health consequences and dietary intervention prospects en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2018-04-07T13:04:36Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1017/S0029665114000597
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Department of Agriculture, Fisheries and the Marine en_US
dc.contributor.sponsor Allen Foundation Inc.Michigan, USA en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1573345
dc.internal.rssid 1570656
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Proceedings Of The Nutrition Society
dc.description.status peer-reviewed

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