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Is matrix gla protein associated with vascular calcification? a systematic review

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dc.contributor.author Barrett, Hilary E.
dc.contributor.author O'Keeffe, Mary
dc.contributor.author Kavanagh, Eamon G.
dc.contributor.author Walsh, Michael T.
dc.contributor.author O'Connor, Eibhlís M.
dc.date.accessioned 2018-04-04T10:34:34Z
dc.date.available 2018-04-04T10:34:34Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6701
dc.description peer-reviewed en_US
dc.description.abstract Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical potential to modify the progression of vascular calcification through regulation of functional MGP fractions. This systematic review examines twenty-eight studies which assess the relationship between circulating protein expressions of MGP species and vascular calcification in different arterial beds. The included studies examined participants with atherosclerosis, chronic kidney disease (CKD), diabetes, healthy participants, vitamin K supplementation, measured plasma vitamin K levels and vitamin K antagonist usage. The current review reports conflicting results regarding MGP fractions with respect to local calcification development indicating that a multifaceted relationship exists between the MGP and calcification. A primary concern regarding the studies in this review is the large degree of variability in the calcification location assessed and the fraction of MGP measured. This review suggests that different underlying molecular mechanisms can accelerate local disease progression within the vasculature, and specific circulating fractions of MGP may be influenced differently depending on the local disease states related to vascular calcification development. Further studies examining the influence of non-functional MGP levels, with respect to specific calcified arterial beds, are warranted. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Nutrients;10, 415
dc.relation.uri http://dx.doi.org/10.3390/nu10040415
dc.subject matrix-gla-protein en_US
dc.subject vascular calcification en_US
dc.subject vitamin K en_US
dc.subject cardiovascular disease en_US
dc.subject atherosclerosis en_US
dc.subject chronic kidney disease en_US
dc.subject diabetes en_US
dc.subject healthy participants en_US
dc.title Is matrix gla protein associated with vascular calcification? a systematic review en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/nu10040415
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor Irish Heart Foundation en_US
dc.relation.projectid GOIPG/2013/1309 en_US
dc.relation.projectid 1102357 en_US
dc.relation.projectid GOIPG/2013/1309
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2858914


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