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Experimental study on the influence of excipients on the heterogeneous crystallization and dissolution properties of an active pharmaceutical ingredient

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dc.contributor.author Verma, Vivek
dc.contributor.author Peddapatla, Raghu V.G.
dc.contributor.author Crowley, Clare M.
dc.contributor.author Crean, Abina M.
dc.contributor.author Davern, Peter
dc.contributor.author Hudson, Sarah P.
dc.contributor.author Hodnett, Benjamin K.
dc.date.accessioned 2018-02-23T10:10:17Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6599
dc.description peer-reviewed en_US
dc.description.abstract This study is based on the heterogeneous nucleation of active pharmaceutical ingredients (APIs) in the presence of various excipients widely used in the pharmaceutical industry. Carbamazepine (CBMZ) was successfully crystallized in the presence of the following heterosurfaces: alpha/beta-lactose, beta-D-mannitol, micro crystalline cellulose, and carboxymethyl cellulose. The successful crystallization of CBMZ FIII in the presence of all the excipients was confirmed by powder X-ray diffraction and scanning electron microscopy, while CBMZ crystals' apposition was confirmed using in situ scanning electronic microscopy-Raman. A pronounced improvement in the dissolution of CBMZ FIII was observed when crystallized in the presence of excipients when compared with CBMZ FIII recrystallized using the same conditions in the absence of the excipients. The isolated solids could be simply tabletted by direct compression upon mixing with the desired amount of disintegrant and lubricant. Hence employing this process could potentially streamline the downstream process in pharmaceutical industries and also increase the throughput with reduced cost. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Crystal Growth and Design;18, (1), pp. 338-350
dc.relation.uri http://dx.doi.org/10.1021/acs.cgd.7b01336
dc.rights © 2018 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal Title, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.7b01336 en_US
dc.subject heterogeneous nucleation en_US
dc.subject active pharmaceutical ingredients en_US
dc.subject excipients en_US
dc.subject carbamazepine en_US
dc.title Experimental study on the influence of excipients on the heterogeneous crystallization and dissolution properties of an active pharmaceutical ingredient en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2018-02-23T09:59:16Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1021/acs.cgd.7b01336
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12/RC/2275 en_US
dc.date.embargoEndDate 2018-11-30
dc.embargo.terms 2018-11-30 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2736452
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Crystal Growth & Design
dc.description.status peer-reviewed


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