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Brain lateralization in mice is associated with zinc signaling and altered in prenatal zinc deficient mice that display features of autism spectrum disorder

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dc.contributor.author Grabrucker, Stefanie
dc.contributor.author Haderspeck, Jasmin C.
dc.contributor.author Sauer, Ann Katrin
dc.contributor.author Kittelberger, Nadine
dc.contributor.author Asoglu, Harun
dc.contributor.author Abaei, Alireza
dc.contributor.author Rasche, Volker
dc.contributor.author Schon, Michael
dc.contributor.author Boeckers, Tobias M.
dc.contributor.author Grabrucker, Andreas M.
dc.date.accessioned 2018-02-02T09:22:54Z
dc.date.available 2018-02-02T09:22:54Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10344/6522
dc.description peer-reviewed en_US
dc.description.abstract A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many vertebrates, we analyzed whether prenatal zinc deficient (PZD) mice, a mouse model with ASD like behavior, show alterations regarding brain lateralization on molecular and behavioral level. Our results show that hemisphere-specific expression of marker genes is abolished in PZD mice on mRNA and protein level. Using magnetic resonance imaging, we found an increased striatal volume in PZD mice with no change in total brain volume. Moreover, behavioral patterns associated with striatal lateralization are altered and the lateralized expression of dopamine receptor 1 (DR1) in the striatum of PZD mice was changed. We conclude that zinc signaling during brain development has a critical role in the establishment of brain lateralization in mice. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation FP7/2007-2013
dc.relation.ispartofseries Frontiers in Molecular Neuroscience;10:450
dc.rights This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. en_US
dc.subject Zn en_US
dc.subject hemisphere dominance en_US
dc.subject ASD en_US
dc.subject synapse en_US
dc.subject trace metal en_US
dc.subject connectivity en_US
dc.title Brain lateralization in mice is associated with zinc signaling and altered in prenatal zinc deficient mice that display features of autism spectrum disorder en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fnmol.2017.00450
dc.contributor.sponsor Else-Kröner-Fresenius Stiftung en_US
dc.contributor.sponsor Juniorprofessuren-Program en_US
dc.contributor.sponsor Boehringer Ingelheim Ulm University BioCenter (Program BIU2) en_US
dc.contributor.sponsor Innovative Medicines Initiative (IMI) en_US
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor EFPIA en_US
dc.relation.projectid 214_A251 en_US
dc.relation.projectid 115300 en_US
dc.relation.projectid FP7/2007-2013 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2736752


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