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Fabry-Pérot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment

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dc.contributor.author Viphavakit, Charusluk
dc.contributor.author Duraibabu, Dinesh Babu
dc.contributor.author O'Keeffe, Sinéad
dc.contributor.author Lewis, Elfed
dc.date.accessioned 2018-01-25T16:42:55Z
dc.date.available 2018-01-25T16:42:55Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/6494
dc.description peer-reviewed en_US
dc.description.abstract An optical fiber sensor based on Fabry-Pérot interferometer to measure the refractive index changes due to oxygenation level changes in hypoxic tumors for radiotherapy treatments is proposed. The sensors have an outer diameter of 220μm with a 20-30μm length air-cavity and a 30μm thickness end cap located at the tip of the sensor. The sensors are used to measure the phase change in the received optical spectrum when there is a change in refractive index using a Fast Fourier Transform based analysis method. The refractive index change is measured in order to determine the oxygenation level in hypoxic tumors. In this paper, different concentrations of iso-propanol solution are prepared to produce refractive index values between 1.3438 and 1.3655 in order to mimic the refractive index of hemoglobin. The sensors are coated with a 100 nm thick gold layer and a comparison is made with non-coated sensors. The coated sensors have a resolution in order of 10-3 RIU. en_US
dc.language.iso eng en_US
dc.publisher Society of Photo-optical Instrumentation Engineers en_US
dc.relation.ispartof Optical Fiber Sensors Conference (OFS), 2017 25th en
dc.relation.ispartofseries 25th International Conference on Optical Fiber Sensors;10323
dc.relation.uri http://dx.doi.org/10.1117/12.2265084
dc.rights © 2017Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited en_US
dc.subject Fabry-Pérot interferometer en_US
dc.subject refractive index sensors en_US
dc.subject hypoxic tumors en_US
dc.title Fabry-Pérot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment en_US
dc.type info:eu-repo/semantics/conferenceObject en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2018-01-25T16:33:31Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1117/12.2265084
dc.contributor.sponsor IRC en_US
dc.relation.projectid EPSPD/2015/36 en_US
dc.relation.projectid EPSPG/2011/343 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2735826
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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