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On the mechanical behaviour of carotid artery plaques:the influence of curve-fitting experimental data on numerical model results

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dc.contributor.author Mulvihill, John J.
dc.contributor.author Walsh, Michael T.
dc.date.accessioned 2018-01-12T16:17:13Z
dc.date.available 2018-01-12T16:17:13Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/10344/6439
dc.description peer-reviewed en_US
dc.description.abstract Computational models of diseased arteries are advancing rapidly, and a need exists to develop more accurate material models of human atherosclerotic plaques. However, intact samples for in vitro mechanical testing are not readily available. Most plaque samples are harvested from carotid endarterectomies where the geometries are not suitable for the boundary parameters necessary for classical uniaxial tensile testing. Experimental studies of biological tissue, particularly human plaque tissue, have not specified the minimum width-to-length (WL) ratio necessary for appropriate tensile testing. This study proposes either tensile or planar shear testing on whole specimen samples depending on the WL ratio. However, a “grey-area” of WL ratios exists which are unsuitable for either test, between 0.5:1 and 4:1 WL ratio. Eighteen plaque samples are investigated in this study, and according to classical approaches, two of the plaque samples have WL ratios suitable for tensile testing and four are suitable for planar shear testing. The remaining twelve samples fall in the grey-area of WL ratio. The study analyses which test method is suitable for the samples in this grey-area and what effect using the incorrect test method has on results from a computational model. The study highlights that tissues above a WL ratio of 2:1 are suitable for planar shear testing, and samples below 1:1 are more suited for tensile testing. Therefore, the “grey-area” can be reduced with certain limitations applied by the minor strain assumption which need to be taken into account during experimental testing. This study also demonstrates the influence of curve-fitting experimental results using tensile- and planar shear–based boundary parameters from eighteen plaque samples. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Biomechanics and Modeling in Mechanobiology;12 (5), pp. 975-985
dc.relation.uri http://dx.doi.org/10.1007/s10237-012-0457-9
dc.rights The original publication is available at www.springerlink.com en_US
dc.subject carotid artery disease en_US
dc.subject plaque properties en_US
dc.subject mechanical characterisation en_US
dc.subject modelling approaches en_US
dc.title On the mechanical behaviour of carotid artery plaques:the influence of curve-fitting experimental data on numerical model results en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1007/s10237-012-0457-9
dc.contributor.sponsor IRC en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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