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Deformation of the lamina cribrosa and optic nerve due to changes in cerebrospinal fluid pressure

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dc.contributor.author Feola, Andrew J.
dc.contributor.author Coudrillier, Baptiste
dc.contributor.author Mulvihill, John J.
dc.contributor.author Geraldes, Diogo M.
dc.contributor.author Vo, Nghia T.
dc.contributor.author Albon, Julie
dc.contributor.author Abel, Richard L.
dc.contributor.author Samuels, Brian C.
dc.contributor.author Ross Ethier, C.
dc.date.accessioned 2018-01-05T11:40:08Z
dc.date.available 2018-01-05T11:40:08Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/6404
dc.description peer-reviewed en_US
dc.description.abstract PURPOSE. Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased. METHODS. The posterior eye and RLNT of porcine eyes (n ¼ 3) were imaged using synchrotron radiation phase-contrast micro-computed tomography (PC lCT) at an intraocular pressure of 15 mm Hg and CSFps of 4, 10, 20, and 30 mm Hg. Scans of each tissue region were acquired at each CSFp step and analyzed using digital volume correlation to determine 3-dimensional tissue deformations. RESULTS. Elevating CSFp increased the strain in the lamina cribrosa and RLNT of all three specimens, with the largest strains occurring in the RLNT. Relative to the baseline CSFp of 4 mm Hg, at 30 mm Hg, the lamina cribrosa experienced a mean first and third principal strain of 4.4% and 3.5%, respectively. The corresponding values for the RLNT were 9.5% and 9.1%. CONCLUSIONS. CSFp has a significant impact on the strain distributions within the lamina cribrosa and, more prominently, within the RLNT. Elevations in CSFp were positively correlated with increasing deformations in each region and may play a role in ocular pathologies linked to changes in CSFp. en_US
dc.language.iso eng en_US
dc.publisher Association for Research in Vision and Ophthalmology en_US
dc.relation.ispartofseries Investigative Ophthalmology & Visual Science;58 (4), pp. 2070-2078
dc.relation.uri http://dx.doi.org/10.1167/iovs.16-21393
dc.subject cerebrospinal fluid pressure en_US
dc.subject digital volume correlation en_US
dc.subject intracranial pressure en_US
dc.subject ocular biomechanics en_US
dc.subject phase-contrast micro-computed tomography en_US
dc.title Deformation of the lamina cribrosa and optic nerve due to changes in cerebrospinal fluid pressure en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1167/iovs.16-21393
dc.contributor.sponsor Science and Technology Facilities Council en_US
dc.contributor.sponsor Georgia Research Alliance en_US
dc.contributor.sponsor National Aeronautics and Space Administration en_US
dc.relation.projectid EE8491 en_US
dc.relation.projectid EE9825 en_US
dc.relation.projectid EE11407 en_US
dc.relation.projectid NNX13AP91G en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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