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The association of serum levels of brain-derived neurotrophic factor with the occurrence of and recovery from delirium in older medical inpatients

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dc.contributor.author Williams, John
dc.contributor.author Finn, Karen
dc.contributor.author Melvin, Vincent
dc.contributor.author Meagher, David
dc.contributor.author McCarthy, Geraldine
dc.contributor.author Adamis, Dimitrios
dc.date.accessioned 2017-12-21T15:44:17Z
dc.date.available 2017-12-21T15:44:17Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/6382
dc.description peer-reviewed en_US
dc.description.abstract Limited studies of the association between BDNF levels and delirium have given inconclusive results. This prospective, longitudinal study examined the relationship between BDNF levels and the occurrence of and recovery from delirium. Participants were assessed twice weekly using MoCA, DRS-R98, and APACHE II scales. BDNF levels were estimated using an ELISA method. Delirium was defined with DRS-R98 (score > 16) and recovery from delirium as ≥2 consecutive assessments without delirium prior to discharge. We identified no difference in BDNF levels between those with and without delirium. Excluding those who never developed delirium (𝑛 = 140), we examined the association of BDNF levels and other variables with delirium recovery. Of 58 who experienced delirium, 39 remained delirious while 19 recovered. Using Generalized Estimating Equations models we found that BDNF levels (Wald 𝜒2 = 7.155; df: 1, 𝑝 = 0.007) and MoCA (Wald 𝜒2 = 4.933; df: 1, 𝑝 = 0.026) were associated with recovery. No significant association was found for APACHE II, dementia, age, or gender. BDNF levels do not appear to be directly linked to the occurrence of delirium but recovery was less likely in those with continuously lower levels. No previous study has investigated the role of BDNF in delirium recovery and these findings warrant replication in other populations. en_US
dc.language.iso eng en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartofseries Biomed Research International;article ID 5271395
dc.subject cognitive impairment en_US
dc.subject plasma-levels en_US
dc.subject cytokines en_US
dc.subject disease en_US
dc.subject withdrawal en_US
dc.subject system en_US
dc.subject injury en_US
dc.title The association of serum levels of brain-derived neurotrophic factor with the occurrence of and recovery from delirium in older medical inpatients en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-12-21T15:33:24Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1155/2017/5271395
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2702193
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Biomed Research International
dc.description.status peer-reviewed


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