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Regime-separated approach for population balance modelling of continuous wet granulation of pharmaceutical formulations

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Show simple item record Shirazian, Saeed Darwish, Shaza Kuhs, Manuel Croker, Denise M. Walker, Gavin M. 2017-12-15T15:39:04Z 2018
dc.description peer-reviewed en_US
dc.description.abstract A two-dimensional population balance model (PBM) was developed in order to predict granule size distribution (GSD) in continuous twin-screw granulation. The model predicts the GSD as well as granule liquid content at different spatial locations. In order to understand the different mechanisms involved in the twin-screw granulation process, a regime-separated approach was used in which the population balance model was solved for different zones along the extruder, i.e. kneading and conveying zones. For the conveying zone, the flow regime was assumed to be plug flow, whereas a well-mixed regime was assumed for modelling of particulate events in the kneading zone. In the development of the population balance model, breakage and aggregation phenomena were considered as particulate events. The unknown parameters of the model were estimated using experimental data obtained for granulation of pure microcrystalline cellulose using a 12 mm twin-screw granulator. Among five experimental runs, three runs were used for model calibration and two runs for validation. The results indicated that the model is rigorous and reliable for prediction of GSD as function of process parameters in twin-screw granulation. Moreover, in order to capture tri-modality in the granule size distribution, a partial wetting approach was used in which 50% of particles were assumed dry at low liquid to solid ratio. The latter assumption resulted in prediction of tri-modal GSD by the developed PBM. The results revealed that aggregation is dominant in the conveying zone, while in the kneading zone the breakage rate is much higher than the aggregation rate. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Power Technology;325, pp. 420-428
dc.rights This is the author’s version of a work that was accepted for publication in Power Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Power Technology, 2017, 325, pp. 420-428, en_US
dc.subject wet granulation en_US
dc.subject continuous pharmaceutical manufacture en_US
dc.subject population balance model en_US
dc.subject mechanistic model en_US
dc.subject twin-screw granulator en_US
dc.subject simulation en_US
dc.title Regime-separated approach for population balance modelling of continuous wet granulation of pharmaceutical formulations en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.powtec.2017.11.047
dc.contributor.sponsor SFI en_US
dc.relation.projectid 13/IA/1980 en_US 2091-11-21
dc.embargo.terms 2091-11-21 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2739639

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