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Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(epsilon-caprolactone) melt extrudates for pharmaceutical applications

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Show simple item record Douglas, P. Albadarin, Ahmad B. Sajjia, M. Mangwandi, Chirangano Kuhs, Manuel Collins, Maurice N. Walker, Gavin M. 2017-12-07T12:45:00Z 2017-12-07T12:45:00Z 2016
dc.description peer-reviewed en_US
dc.description.abstract This paper investigates the effects of polyethylene glycol (PEG), on the mechanical and thermal properties of nalidixic acid/poly ε-caprolactone (NA)/PCL blends prepared by hot melt extrusion. The blends were characterized by tensile and flexural analysis, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction. Results show that loading PEG in the PCL had a detrimental effect on the tensile strength and toughness of the blends, reducing them by 20–40%. The partial miscibility of the PCL-PEG system, causes an increase in Tg. While increases in the crystallinity is attributed to the plasticisation effect of PEG and the nucleation effect of NA. The average crystal size increased by 8% upon PEG addition. Experimental data indicated that the addition of NA caused loss of the tensile strength and toughness of PCL. Thermal analysis of the PCL showed that on addition of the thermally unstable NA, thermal degradation occurred early and was autocatalytic. However, the NA did benefit from the heat shielding provided by the PCL matrix resulting in more thermally stable NA particles en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;500 (1-2), pp. 179-186
dc.rights This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 2016, 500 (1-2), pp, 179-186, en_US
dc.subject mechanical and thermal properties en_US
dc.subject melt extrusion en_US
dc.subject drug formulation en_US
dc.subject poly-caprolactone en_US
dc.subject nalidixic acid en_US
dc.title Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(epsilon-caprolactone) melt extrudates for pharmaceutical applications en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2017-12-07T12:33:33Z
dc.identifier.doi 10.1016/j.ijpharm.2016.01.036
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1631310
dc.internal.rssid 1629780
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle International journal of pharmaceutics
dc.description.status peer-reviewed

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