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In vitro antioxidant and immunomodulatory activity of transglutaminase-treated sodium caseinate hydrolysates

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dc.contributor.author Cermeño Aínsa, María M.
dc.contributor.author Fitzgerald, Richard J.
dc.contributor.author O Brien, Nora M.
dc.date.accessioned 2017-12-07T10:05:48Z
dc.date.available 2017-12-07T10:05:48Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10344/6322
dc.description peer-reviewed en_US
dc.description.abstract Sodium caseinate (NaCN) was incubated prior to and after hydrolysis with a microbial transglutaminase (TGase) and hydrolysed with Prolyve 1000. The resultant hydrolysates were tested for their immunomodulatory and antioxidant activity. TGase-treated hydrolysates significantly reduced (p 0.05) differences were found between the TGase-treated and non-TGase-treated samples. In the presence of hydrogen peroxide, the non-TGase-treated sample exhibited the highest DNA protective effect in U937 cells. These findings suggest that NaCN derived hydrolysates with and without treatment with TGase may exert specific antioxidant, genoprotective and anti-inflammatory effects. (C) 2016 Elsevier Ltd. All rights reserved. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Dairy Journal;63, pp. 107-114
dc.relation.uri http://dx.doi.org/10.1016/j.idairyj.2016.08.007
dc.rights This is the author’s version of a work that was accepted for publication in the International Dairy Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the International Dairy Journal, 2016, 63, pp. 107-114, https://doi.org/10.1016/j.idairyj.2016.08.007 en_US
dc.subject spent grain BSG en_US
dc.subject bioactive peptides en_US
dc.subject oxidative stress en_US
dc.subject milk-proteins en_US
dc.title In vitro antioxidant and immunomodulatory activity of transglutaminase-treated sodium caseinate hydrolysates en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-12-07T09:55:36Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.idairyj.2016.08.007
dc.contributor.sponsor Department of Agriculture, Food and the Marine en_US
dc.relation.projectid 10 RD TMFRC 701 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2691550
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle International Dairy Journal
dc.description.status peer-reviewed


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