University of Limerick Institutional Repository

Raman spectroscopic analysis of fingernail clippings can help differentiate between postmenopausal women who have and have not suffered a fracture

DSpace Repository

Show simple item record

dc.contributor.author Beattie, James R.
dc.contributor.author Cummins, Niamh M.
dc.contributor.author Caraher, Clare
dc.contributor.author O'Driscoll, Olive M.
dc.contributor.author Bansal, Aruna T.
dc.contributor.author Eastell, Richard
dc.contributor.author Ralston, Stuart H.
dc.contributor.author Stone, Michael D.
dc.contributor.author Pearson, Gill
dc.contributor.author Towler, M.R.
dc.date.accessioned 2017-10-26T08:43:35Z
dc.date.available 2017-10-26T08:43:35Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10344/6203
dc.description peer-reviewed en_US
dc.description.abstract Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results from the validation set showed that a novel algorithm, combining spectroscopy data with clinical data, provided area under the curve (AUC) of 74% compared to an AUC of 60% from a reduced QFracture score (a clinically accepted risk calculator) and 61% from the dual-energy X-ray absorptiometry T-score, which is in current use for the diagnosis of osteoporosis. Raman spectroscopy should be investigated further as a noninvasive tool for the early detection of enhanced risk of fragility fracture. en_US
dc.language.iso eng en_US
dc.publisher Libertas Academica en_US
dc.relation.ispartofseries Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders;9 ,pp. 109–116
dc.relation.uri http://dx.doi.org/10.4137/CMAMD.S38493
dc.subject fracture risk en_US
dc.subject raman spectroscopy en_US
dc.subject qfracture en_US
dc.subject osteoporosis en_US
dc.subject bone en_US
dc.subject DEXA en_US
dc.title Raman spectroscopic analysis of fingernail clippings can help differentiate between postmenopausal women who have and have not suffered a fracture en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.4137/CMAMD.S38493
dc.contributor.sponsor Crescent Diagnostics Limited en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


Browse

My Account

Statistics