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Pneumocystis jiroveci prophylaxis in patients undergoing Bendamustine treatment: the need for a standardized protocol

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dc.contributor.advisor
dc.contributor.author Abkur, Tarig Mohammed
dc.contributor.author Saeed, Mamoun
dc.contributor.author Ahmed, Saad Zeinalabdin
dc.contributor.author McArthur, Ryan
dc.contributor.author Leahy, Maeve
dc.contributor.author O'Leary, Hilary
dc.contributor.author O'Keeffe, Denis
dc.date.accessioned 2017-10-13T09:00:02Z
dc.date.available 2017-10-13T09:00:02Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/6155
dc.description peer-reviewed en_US
dc.description.abstract Pneumocystis jiroveci pneumonia (PJP) has been increasingly described as a serious opportunistic infection in HIV seronegative patients with malignancy, as a consequence of immunosuppression from chemotherapy. The standard method for diagnosing PJP is demonstration of Pneumocystis in either bronchoalveolar lavage fluid or induced sputum. Testing with either specimen has a sensitivity ranging from 80 to 95% [1, 2]. Trimethoprim/ sulpfamexazole (TMP/SMX) is the gold standard for treatment and prophylaxis of PJP. The death rate due to PJP ranges between 10 and 20% in patients with HIV [3]. This infection carries a worse prognosis in the HIV seronegative population with a mortality rate of 30 to 60%, possibly as a consequence of late diagnosis and delayed treatment [4]. en_US
dc.language.iso eng en_US
dc.publisher Wiley Open Access en_US
dc.relation.ispartofseries Clinical Case Reports;3, (4) pp. 255–259
dc.relation.uri http://dx.doi.org/10.1002/ccr3.195
dc.subject bendamustine en_US
dc.subject pneumocystis en_US
dc.subject trimethoprim/sulfamethoxazole en_US
dc.title Pneumocystis jiroveci prophylaxis in patients undergoing Bendamustine treatment: the need for a standardized protocol en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/ccr3.195
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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