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Electrospun API-loaded mixed matrix membranes for controlled release

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Show simple item record Castro-Dominguez, Bernardo Moroney, Kevin M. Schaller, Barbara E. O'Connor, S. Cloonan, A. Vo, Tuoi T.N. Walker, Gavin M. O'Reilly, Emmet J. 2017-09-20T07:58:34Z 2017-09-20T07:58:34Z 2017
dc.description peer-reviewed en_US
dc.description.abstract The development of biocompatible membrane materials capable of delivering active pharmaceutical ingredients (APIs) over a fixed time period offers significant advantages to the pharmaceutical and biomedical industries alike. In addition the incorporation of APIs within polymeric materials potentially allows for the formation of amorphous solid dispersions (ASDs), which have shown enhanced bioavailability, increased dissolution profiles and enhanced adsorption into the blood stream. Mixed matrix membranes (MMMs) have been at the forefront of such developments, however manufacturing MMMs with consistent batch to batch physical characteristics has proved challenging thereby significantly impeding the use of such materials by the pharmaceutical sector. This article describes the development, for the first time, of API and molecular sieve loaded mixed matrix membranes (MMMs) via electro spinning techniques. The developed membranes displayed consistent and controllable physical properties and more efficient API release relative to membranes prepared using traditional casting techniques. Mathematical modelling disclosed that the membranes generated via electrospinning show excellent correlation between experimental and predicted API release kinetics thereby paving the way for the development of MMMs for both pharmaceutical and biomedical applications. en_US
dc.language.iso eng en_US
dc.publisher Royal Society of Chemistry en_US
dc.relation.ispartofseries RSC Advances;7 : 43300-43309
dc.subject electrospun en_US
dc.subject api-loaded en_US
dc.subject mixed en_US
dc.subject matrix en_US
dc.subject membranes en_US
dc.subject controlled en_US
dc.subject release en_US
dc.title Electrospun API-loaded mixed matrix membranes for controlled release en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1039/c7ra08600h
dc.contributor.sponsor SFI en_US
dc.relation.projectid 14/SP/2750 en_US
dc.relation.projectid 12/IA/1683 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2723718

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