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The influence of composition and location on the toughness of human atherosclerotic femoral plaque tissue

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dc.contributor.author Cunnane, Eoghan M.
dc.contributor.author Barrett, Hilary E.
dc.contributor.author Kavanagh, Eamon G.
dc.contributor.author Mongrain, R
dc.contributor.author Walsh, Michael T.
dc.date.accessioned 2017-08-30T11:43:05Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10344/6041
dc.description peer-reviewed en_US
dc.description.abstract The toughness of femoral atherosclerotic tissue is of pivotal importance to understanding the mechanism of luminal expansion during cutting balloon angioplasty (CBA) in the peripheral vessels. Furthermore, the ability to relate this parameter to plaque composition, pathological inclusions and location within the femoral vessels would allow for the improvement of existing CBA technology and for the stratification of patient treatment based on the predicted fracture response of the plaque tissue to CBA. Such information may lead to a reduction in clinically observed complications, an improvement in trial results and an increased adoption of the CBA technique to reduce vessel trauma and further endovascular treatment uptake. This study characterises the toughness of atherosclerotic plaque extracted from the femoral arteries of ten patients using a lubricated guillotine cutting test to determine the critical energy release rate. This information is related to the location that the plaque section was removed from within the femoral vessels and the composition of the plaque tissue, determined using Fourier Transform InfraRed spectroscopy, to establish the influence of location and composition on the toughness of the plaque tissue. Scanning electron microscopy (SEM) is employed to examine the fracture surfaces of the sections to determine the contribution of tissue morphology to toughness. Toughness results exhibit large inter and intra patient and location variance with values ranging far above and below the toughness of healthy porcine arterial tissue (Range: 1330–3035 for location and 140–4560 J/m2 for patients). No significant difference in mean toughness is observed between patients or location. However, the composition parameter representing the calcified tissue content of the plaque correlates significantly with sample toughness (r = 0.949, p < 0.001). SEM reveals the presence of large calcified regions in the toughest sections that are absent from the least tough sections. Regression analysis highlights the potential of employing the calcified tissue content of the plaque as a preoperative tool for predicting the fracture response of a target lesion to CBA (R2 = 0.885, p < 0.001). en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Acta Biomaterialia;31, pp. 264-275
dc.relation.uri http://dx.doi.org/10.1016/j.actbio.2015.11.056
dc.rights This is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomaterialia, 2016, 31, pp. 264-275, http://dx.doi.org/10.1016/j.actbio.2015.11.056 en_US
dc.subject femoral artery en_US
dc.subject atherosclerotic plaque en_US
dc.subject tissue characterisation en_US
dc.subject toughness en_US
dc.subject fracture en_US
dc.title The influence of composition and location on the toughness of human atherosclerotic femoral plaque tissue en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-08-30T11:34:52Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.actbio.2015.11.056
dc.date.embargoEndDate 2017-12-07
dc.embargo.terms 2017-12-07 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1631703
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Acta Biomaterialia
dc.description.status peer-reviewed


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