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New and emerging SXT/R391 integrative conjugative elements as vehicles for stable mobile element transfer and spread of antibiotic resistance in both human and animals.

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dc.contributor.author Ryan, Michael P.
dc.contributor.author Armshaw, Patricia
dc.contributor.author Pembroke, Tony J.
dc.date.accessioned 2017-08-17T10:27:49Z
dc.date.available 2017-08-17T10:27:49Z
dc.date.issued 2017
dc.identifier.isbn 978-84-947512-0-2
dc.identifier.uri http://hdl.handle.net/10344/5994
dc.description peer-reviewed en_US
dc.description.abstract The integrative conjugative elements, ICE s SXT and R391 are the prototypes of a group of gram negative integrative elements known as the SXT/R391 group. R391 was identified in a clinical isolate of Providencia in the late 1960 s in South Africa, while SXT was initially isolated in 1992 in a clinical isolate of Vibrio cholerae O139 and variants have since been isolated in pandemic strains throughout the world. Subsequent sequencing of both elements demonstrated a high degree of structural similarity leading to the group being classified as the SXT/R391 group. The SXT/R391 ICE elements are characterised as integrating into a specific chromosomal site within gram ve hosts, being extremely stable and promiscuous and possessing a number of element hotspots for integration of heterologous DNA including increasingly, antibiotic resistance determinants. This makes such ICE s highly adapted for antibiotic spread. New evidence emerging indicates that SXT/R391-like ICE s are increasingly being identified worldwide particularly in Asia not only from Vibrio species, where they have been found widely in human clinical isolates, but from other gram -ve associated infections of domestic animals and fish. Evidence of more such elements may emerge in the future as a new trapping vector pIceCap has been developed to capture them in a circular form, aiding characterisation. The types of the novel ICE s now emerging, their comparison with prototype elements and the antibiotic resistances associated with them are important given their promiscuous nature and stability.  en_US
dc.language.iso eng en_US
dc.publisher Formatex en_US
dc.relation.ispartofseries Antimicrobial research: Novel bioknowledge and educational programs,Méndez-Vilas, A (ed);
dc.subject SXT/R391-like ICE's en_US
dc.subject stable mobile elements en_US
dc.subject antibiotic resistance spread en_US
dc.title New and emerging SXT/R391 integrative conjugative elements as vehicles for stable mobile element transfer and spread of antibiotic resistance in both human and animals. en_US
dc.type info:eu-repo/semantics/bookPart en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-08-15T09:17:54Z
dc.description.version PUBLISHED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2719273
dc.internal.copyrightchecked Yes
dc.description.status Peer reviewed


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