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Improving risk factor management for patients with poorly controlled type 2 diabetes: a systematic review of healthcare interventions in primary care and community settings

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dc.contributor.author Murphy, Mark E
dc.contributor.author Byrne, Molly
dc.contributor.author Galvin, Rose
dc.contributor.author Boland, Fiona
dc.contributor.author Fahey, Tom
dc.contributor.author Smith, Susan M.
dc.date.accessioned 2017-08-09T09:17:57Z
dc.date.available 2017-08-09T09:17:57Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/5953
dc.description peer-reviewed en_US
dc.description.abstract Objectives Poorly controlled type 2 diabetes mellitus (T2DM) is a major international health problem. Our aim was to assess the effectiveness of healthcare interventions, specifically targeting patients with poorly controlled T2DM, which seek to improve glycaemic control and cardiovascular risk in primary care settings. Design Systematic review. Setting Primary care and community settings. Included studies Randomised controlled trials (RCTs) targeting patients with poor glycaemic control were identified from Pubmed, Embase, Web of Science, Cochrane Library and SCOPUS. Poor glycaemic control was defined as HbA1c over 59 mmol/mol (7.5%). Interventions Interventions were classified as organisational, patient-oriented, professional, financial or regulatory. Outcomes Primary outcomes were HbA1c, blood pressure and lipid control. Two reviewers independently assessed studies for eligibility, extracted data and assessed study quality. Meta-analyses were undertaken where appropriate using random-effects models. Subgroup analysis explored the effects of intervention type, baseline HbA1c, study quality and study duration. Meta-regression analyses were undertaken to investigate identified heterogeneity. Results Forty-two RCTs were identified, including 11 250 patients, with most undertaken in USA. In general, studies had low risk of bias. The main intervention types were patient-directed (48%) and organisational (48%). Overall, interventions reduced HbA1c by −0.34% (95% CI −0.46% to −0.22%), but meta-analyses had high statistical heterogeneity. Subgroup analyses suggested that organisational interventions and interventions on those with baseline HbA1c over 9.5% had better improvements in HbA1c. Meta-regression analyses suggested that only interventions on those with population HbA1c over 9.5% were more effective. Interventions had a modest improvement of blood pressure and lipids, although baseline levels of control were generally good. Conclusions This review suggests that interventions for T2DM, in primary care, are better targeted at individuals with very poor glycaemic control and that organisational interventions may be more effective. en_US
dc.language.iso eng en_US
dc.publisher BMJ Publishing Group en_US
dc.relation.ispartofseries BMJ Open;e015135
dc.subject type 2 diabetes en_US
dc.subject risk factor en_US
dc.subject management en_US
dc.title Improving risk factor management for patients with poorly controlled type 2 diabetes: a systematic review of healthcare interventions in primary care and community settings en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1136/bmjopen-2016-015135
dc.contributor.sponsor HRB en_US
dc.relation.projectid HRC-2014-1 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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