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Expression of protein kinase C gamma promotes cell migration in colon cancer

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Show simple item record Dowling, Catríona M. Hayes, Sheri L. Phelan, James L. Cathcart, Mary Clare Finn, Stephen P. Mehigan, Brian McCormick, Paul Coffey, John C. O'Sullivan, Jacintha Kiely, Patrick A. 2017-07-18T15:21:13Z 2017-07-18T15:21:13Z 2017
dc.description peer-reviewed en_US
dc.description.abstract Despite extensive efforts, Protein Kinase Cs (PKCs) have proven to be an intractable target in cancer therapies. Traditionally it was accepted that PKCs act as tumour promoters, however new research suggests that PKCs may play an important role in the suppression of cancer. A challenge in targeting PKCs is the limited data available in patient samples. One of the PKC isozymes, PKC gamma, is thought to be present only in the brain and has been largely neglected in the context of cancer. Analysis of gene expression levels of PKC gamma in patient matched normal and colon cancer tissue samples revealed an up-regulation of the gene in the cancer tissue of 54% of the patients examined. Mechanistically we demonstrate that a reduction in the levels of PKC gamma in the colon cancer cells inhibits cell migration and foci formation. Further to this, we observe an increase in cell adhesion and proliferation following the reduction of PKC gamma levels in the cell. Thus, PKC gamma plays a key role in colon cancer; making it an important isozyme that needs to be reconsidered in the context of cancer therapies. en_US
dc.language.iso eng en_US
dc.publisher Impact Journals en_US
dc.relation.ispartofseries Oncontarget;pp. 1-12
dc.subject protein kinase C gamma en_US
dc.subject tumor en_US
dc.subject promoter en_US
dc.subject colon cancer en_US
dc.title Expression of protein kinase C gamma promotes cell migration in colon cancer en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.18632/oncotarget.18916
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2719880

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