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High vitamin D levels may downregulate inflammation in patients with Behcet's disease

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dc.contributor.author Adeeb, Fahd
dc.contributor.author Usman Khan, Maria
dc.contributor.author Li, Xia
dc.contributor.author Stack, Austin G.
dc.contributor.author Devlin, Joseph
dc.contributor.author Fraser, Alexander D.
dc.date.accessioned 2017-07-17T11:10:32Z
dc.date.available 2017-07-17T11:10:32Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/5895
dc.description peer-reviewed en_US
dc.description.abstract Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health systemandmatched in 1 : 5 ratio for age, sex, and themonth of the year. 25(OH)Dlevels <20 nmol/Lwere classified as deficientwhile levels between 20 and 40 nmol/Lwere classified as insufficient. Differences between groupswere assessed usingMann–Whitney test and associations between cases and controls were expressed as odds ratios and 95% confidence intervals.Nineteen patients with BD were compared with 95 controls matched by age, sex, and month of blood draw. 25(OH)D levels were significantly higher in patients in BD than in matched controls (median values: 45 nmol/L versus 22 nmol/L, 𝑝 < 0.005) and tended to be lower in patients with active disease than in those without (median values: 35 nmol/L (IQR: 22.75–47.25 nm/L) versus 50 nmol/L (IQR: 35–67 nmol/L), 𝑝 = 0.11). Compared to controls, patients with BD were significantly less likely to have 25(OH)D deficiency or insufficiency (OR: 0.09, 95% CI: 0.03–0.28, 𝑝 < 0.001). Our findings suggest a possible role for 25(OH)D in modifying the inflammatory response in BD and uncover a potential opportunity to assess whether correction of Vit D deficiency confers protective benefits. en_US
dc.language.iso eng en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartofseries International Journal of Inflamation;article ID 8608716
dc.subject D deficiency en_US
dc.subject rheumatoid-arthritis en_US
dc.subject gut microbiota en_US
dc.subject dentritic cells en_US
dc.subject immune system en_US
dc.subject Irish adults en_US
dc.title High vitamin D levels may downregulate inflammation in patients with Behcet's disease en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-07-17T10:59:27Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1155/2017/8608716
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2717276
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle International Journal Of Inflammation
dc.description.status peer-reviewed


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